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dc.contributor.authorSchuppert, C
dc.contributor.authorPaul, A
dc.contributor.authorNill, S
dc.contributor.authorSchwahofer, A
dc.contributor.authorDebus, J
dc.contributor.authorSterzing, F
dc.coverage.spatialNetherlands
dc.date.accessioned2022-09-01T09:27:49Z
dc.date.available2022-09-01T09:27:49Z
dc.date.issued2020-07-01
dc.identifierS2405-6316(20)30034-8
dc.identifier.citationPhysics and Imaging in Radiation Oncology, 2020, 15 pp. 16 - 22en_US
dc.identifier.issn2405-6316
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5364
dc.identifier.eissn2405-6316
dc.identifier.eissn2405-6316
dc.identifier.doi10.1016/j.phro.2020.06.008
dc.description.abstractBACKGROUND AND PURPOSE: Combined photon intensity-modulated radiotherapy (IMRT) and sequential dose-escalated carbon ion beam therapy (IBT) is a technically advanced treatment option for head and neck malignancies. We proposed and evaluated an integrated planning strategy as opposed to an established and largely separated planning workflow. MATERIALS AND METHODS: Ten patients with representative malignancies of the head and neck region underwent combined carbon-photon radiotherapy (RT) in our facilities. Clinical plans were created according to the separated workflow with independent optimization stages for both modalities. Experimental plans incorporated the existing carbon IBT dose distribution into the optimization stage of a step-and-shoot photon IMRT (bias dose planning). RESULTS: Cumulative dose distributions showed statistically significant differences between the two planning strategies and were predominantly in favor of the integrated approach. As such, target irradiation was generally maintained or even improved in a subset of metrics, while normal tissue sparing was widely enhanced; for instance, in the ipsilateral temporal lobe with median Dmean of -16% (p < 0.001). Maximum doses D1% (with adjustment for different fractionation) fell below thresholds for toxicity risk in a minority of instances, where they were previously exceeded. Integral dose did not differ significantly. CONCLUSIONS: Our findings indicate that combination planning of carbon-photon RT for head and neck malignancies may benefit from a proposed bias dose method, yielding favorable dose distribution characteristics and a streamlined planning workflow with fewer plan revisions. Further research is necessary to validate these observations in terms of robustness and their potential for higher tumor control.
dc.formatElectronic-eCollection
dc.format.extent16 - 22
dc.languageeng
dc.language.isoengen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofPhysics and Imaging in Radiation Oncology
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectAdenoid cystic
dc.subjectCarcinoma
dc.subjectCombined modality therapy
dc.subjectComputer-assisted
dc.subjectHead and neck neoplasms
dc.subjectHeavy ion radiotherapy
dc.subjectRadiotherapy
dc.subjectRadiotherapy planning
dc.subjectRadiotherapy, Intensity-modulated
dc.titleA treatment planning study of combined carbon ion-beam plus photon intensity-modulated radiotherapy.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-06-29
dc.date.updated2022-09-01T09:27:18Z
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1016/j.phro.2020.06.008en_US
rioxxterms.licenseref.startdate2020-07-01
rioxxterms.typeJournal Article/Reviewen_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33458321
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished online
pubs.volume15
icr.researchteamRadiother Phys Modellingen_US
dc.contributor.icrauthorNill, Simeon
icr.provenanceDeposited by Mr Arek Surman on 2022-09-01. Deposit type is initial. No. of files: 1. Files: A treatment planning study of combined carbon ion-beam plus photon intensity-modulated radiotherapy.pdf


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/