dc.contributor.author | Coati, I | |
dc.contributor.author | Lotz, G | |
dc.contributor.author | Fanelli, GN | |
dc.contributor.author | Brignola, S | |
dc.contributor.author | Lanza, C | |
dc.contributor.author | Cappellesso, R | |
dc.contributor.author | Pellino, A | |
dc.contributor.author | Pucciarelli, S | |
dc.contributor.author | Spolverato, G | |
dc.contributor.author | Guzzardo, V | |
dc.contributor.author | Munari, G | |
dc.contributor.author | Zaninotto, G | |
dc.contributor.author | Scarpa, M | |
dc.contributor.author | Mastracci, L | |
dc.contributor.author | Farinati, F | |
dc.contributor.author | Realdon, S | |
dc.contributor.author | Pilati, P | |
dc.contributor.author | Lonardi, S | |
dc.contributor.author | Valeri, N | |
dc.contributor.author | Rugge, M | |
dc.contributor.author | Kiss, A | |
dc.contributor.author | Loupakis, F | |
dc.contributor.author | Fassan, M | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-09-02T08:14:02Z | |
dc.date.available | 2022-09-02T08:14:02Z | |
dc.date.issued | 2019-07-30 | |
dc.identifier | 10.1038/s41416-019-0508-4 | |
dc.identifier.citation | British Journal of Cancer, 2019, 121 (3), pp. 257 - 263 | en_US |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5373 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/s41416-019-0508-4 | |
dc.description.abstract | BACKGROUND: Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform of CLDN18, the Claudin 18.2, has recently emerged as an innovative drug target for metastatic gastric cancer. METHODS: We investigated the immunohistochemical profile of CLDN18, p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in a large series of 523 primary gastric carcinomas (GCs; n = 408) and gastro-oesophageal carcinomas (GECs; n = 115) and 135 matched and synchronous nodal metastases. The status of HER2 and EBER by means of chromogenic in situ hybridisation (CISH) was also evaluated. RESULTS: High membranous CLDN18 expression was present in 150/510 (29.4%) primary cases and in 45/132 (34.1%) metastases. An abnormal expression (i.e. nuclear and/or cytoplasmic) was observed in 115 (22.5%) primary cases and in 33 (25.0%) metastases. A 38.8% of the cases showed significant CLDN18 intratumoural variability among the different tissue microarray cores obtained from the same tumour. Positive membrane CLDN18 expression was statistically associated with non-antral GCs (p = 0.016), Lauren diffuse type (p = 0.009), and with EBV-associated cancers (p < 0.001). CONCLUSIONS: CLDN18 is frequently expressed in gastric and gastro-oesophageal cancers; further studies should investigate the prognostic significance of CLDN18 heterogeneity in order to implement its test into clinical practice. | |
dc.format | Print-Electronic | |
dc.format.extent | 257 - 263 | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.ispartof | British Journal of Cancer | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Adenocarcinoma | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Claudins | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | RNA, Viral | |
dc.subject | Stomach Neoplasms | |
dc.subject | Tissue Array Analysis | |
dc.title | Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-06-05 | |
dc.date.updated | 2022-09-02T08:13:43Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s41416-019-0508-4 | en_US |
rioxxterms.licenseref.startdate | 2019-07-30 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31235864 | |
pubs.issue | 3 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41416-019-0508-4 | |
pubs.volume | 121 | |
icr.researchteam | GI Cancer Biol & Genomics | en_US |
dc.contributor.icrauthor | Valeri, Nicola | |
icr.provenance | Deposited by Mr Arek Surman on 2022-09-02. Deposit type is initial. No. of files: 1. Files: Claudin-18 expression in oesophagogastric adenocarcinomas a tissue microarray study of 523 molecularly profiled cases.pdf | |