dc.contributor.author | Wilkinson, MJ | |
dc.contributor.author | Snow, H | |
dc.contributor.author | Downey, K | |
dc.contributor.author | Thomas, K | |
dc.contributor.author | Riddell, A | |
dc.contributor.author | Francis, N | |
dc.contributor.author | Strauss, DC | |
dc.contributor.author | Hayes, AJ | |
dc.contributor.author | Smith, MJF | |
dc.contributor.author | Messiou, C | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-09-02T08:46:30Z | |
dc.date.available | 2022-09-02T08:46:30Z | |
dc.date.issued | 2021-01-08 | |
dc.identifier | ARTN zraa005 | |
dc.identifier | 6104886 | |
dc.identifier.citation | BJS Open, 2021, 5 (1), pp. zraa005 - | |
dc.identifier.issn | 2474-9842 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5377 | |
dc.identifier.eissn | 2474-9842 | |
dc.identifier.eissn | 2474-9842 | |
dc.identifier.doi | 10.1093/bjsopen/zraa005 | |
dc.description.abstract | BACKGROUND: Diagnosis of lymph node (LN) metastasis in melanoma with non-invasive methods is challenging. The aim of this study was to evaluate the diagnostic accuracy of six LN characteristics on CT in detecting melanoma-positive ilioinguinal LN metastases, and to determine whether inguinal LN characteristics can predict pelvic LN involvement. METHODS: This was a single-centre retrospective study of patients with melanoma LN metastases at a tertiary cancer centre between 2008 and 2016. Patients who had preoperative contrast-enhanced CT assessment and ilioinguinal LN dissection were included. CT scans containing significant artefacts obscuring the pelvis were excluded. CT scans were reanalysed for six LN characteristics (extracapsular spread (ECS), minimum axis (MA), absence of fatty hilum (FH), asymmetrical cortical nodule (CAN), abnormal contrast enhancement (ACE) and rounded morphology (RM)) and compared with postoperative histopathological findings. RESULTS: A total of 90 patients were included. Median age was 58 (range 23-85) years. Eighty-eight patients (98 per cent) had pathology-positive inguinal disease and, of these, 45 (51 per cent) had concurrent pelvic disease. The most common CT characteristics found in pathology-positive inguinal LNs were MA greater than 10 mm (97 per cent), ACE (80 per cent), ECS (38 per cent) and absence of RM (38 per cent). In multivariable analysis, inguinal LN characteristics on CT indicative of pelvic disease were RM (odds ratio (OR) 3.3, 95 per cent c.i. 1.2 to 8.7) and ECS (OR 4.2, 1.6 to 11.3). Cloquet's node is known to be a poor predictor of pelvic spread. Pelvic LN disease was present in 50 per cent patients, but only 7 per cent had a pathology-positive Cloquet's node. CONCLUSION: Additional CT radiological characteristics, especially ECS and RM, may improve diagnostic accuracy and aid clinical decisions regarding the need for inguinal or ilioinguinal dissection. | |
dc.format | Print | |
dc.format.extent | zraa005 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.relation.ispartof | BJS Open | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Female | |
dc.subject | Groin | |
dc.subject | Humans | |
dc.subject | Logistic Models | |
dc.subject | Lymph Node Excision | |
dc.subject | Lymph Nodes | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Male | |
dc.subject | Melanoma | |
dc.subject | Middle Aged | |
dc.subject | Pelvis | |
dc.subject | Retrospective Studies | |
dc.subject | Skin Neoplasms | |
dc.subject | Tomography, X-Ray Computed | |
dc.subject | Young Adult | |
dc.title | CT diagnosis of ilioinguinal lymph node metastases in melanoma using radiological characteristics beyond size and asymmetry. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-08-27 | |
dc.date.updated | 2022-09-02T08:45:54Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1093/bjsopen/zraa005 | |
rioxxterms.licenseref.startdate | 2021-01-08 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33609385 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1093/bjsopen/zraa005 | |
pubs.volume | 5 | |
icr.researchteam | Sarcoma&Melanoma Surgery | |
icr.researchteam | Translational Sarcoma, Melanoma and Rare Tumour Surgery | |
dc.contributor.icrauthor | Smith, Myles | |
icr.provenance | Deposited by Mr Arek Surman on 2022-09-02. Deposit type is initial. No. of files: 1. Files: CT diagnosis of ilioinguinal lymph node metastases in melanoma using radiological characteristics beyond size and asymmetry..pdf | |