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dc.contributor.authorKooreman, ES
dc.contributor.authorvan Houdt, PJ
dc.contributor.authorKeesman, R
dc.contributor.authorvan Pelt, VWJ
dc.contributor.authorNowee, ME
dc.contributor.authorPos, F
dc.contributor.authorSikorska, K
dc.contributor.authorWetscherek, A
dc.contributor.authorMüller, A-C
dc.contributor.authorThorwarth, D
dc.contributor.authorTree, AC
dc.contributor.authorvan der Heide, UA
dc.identifier.citationFrontiers in Oncology, 2021, 11 pp. 705964 -
dc.description.abstractPURPOSE: Daily quantitative MR imaging during radiotherapy of cancer patients has become feasible with MRI systems integrated with linear accelerators (MR-linacs). Quantitative images could be used for treatment response monitoring. With intravoxel incoherent motion (IVIM) MRI, it is possible to acquire perfusion information without the use of contrast agents. In this multicenter study, daily IVIM measurements were performed in prostate cancer patients to identify changes that potentially reflect response to treatment. MATERIALS AND METHODS: Forty-three patients were included, treated with 20 fractions of 3 Gy on a 1.5 T MR-linac. IVIM measurements were performed on each treatment day. The diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*) were calculated based on the median signal intensities in the non-cancerous prostate and the tumor. Repeatability coefficients (RCs) were determined based on the first two treatment fractions. Separate linear mixed-effects models were constructed for the three IVIM parameters. RESULTS: In total, 726 fractions were analyzed. Pre-treatment average values, measured on the first fraction before irradiation, were 1.46 × 10-3 mm2/s, 0.086, and 28.7 × 10-3 mm2/s in the non-cancerous prostate and 1.19 × 10-3 mm2/s, 0.088, and 28.9 × 10-3 mm2/s in the tumor, for D, f, and D*, respectively. The repeatability coefficients for D, f, and D* in the non-cancerous prostate were 0.09 × 10-3 mm2/s, 0.05, and 15.3 × 10-3 mm2/s. In the tumor, these values were 0.44 × 10-3 mm2/s, 0.16, and 76.4 × 10-3 mm2/s. The mixed effects analysis showed an increase in D of the tumors over the course of treatment, while remaining stable in the non-cancerous prostate. The f and D* increased in both the non-cancerous prostate and tumor. CONCLUSIONS: It is feasible to perform daily IVIM measurements on an MR-linac system. Although the repeatability coefficients were high, changes in IVIM perfusion parameters were measured on a group level, indicating that IVIM has potential for measuring treatment response.
dc.format.extent705964 -
dc.relation.ispartofFrontiers in Oncology
dc.subjectintravoxel incoherent motion
dc.subjectprostate cancer
dc.subjectquantitative MRI
dc.subjecttreatment response
dc.titleDaily Intravoxel Incoherent Motion (IVIM) In Prostate Cancer Patients During MR-Guided Radiotherapy-A Multicenter Study.
dc.typeJournal Article
rioxxterms.typeJournal Article/Review
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance Imaging in Radiotherapy
pubs.publication-statusPublished online
icr.researchteamMagnet Resonance Imaging
dc.contributor.icrauthorWetscherek, Andreas
icr.provenanceDeposited by Mr Arek Surman on 2022-09-02. Deposit type is initial. No. of files: 1. Files: Daily Intravoxel Incoherent Motion (IVIM) In Prostate Cancer Patients During MR-Guided Radiotherapy-A Multicenter Study.pdf

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