dc.contributor.author | Khalique, S | |
dc.contributor.author | Nash, S | |
dc.contributor.author | Natrajan, R | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-09-06T15:08:56Z | |
dc.date.available | 2022-09-06T15:08:56Z | |
dc.date.issued | 2022-06-29 | |
dc.identifier.citation | Journal of Pathology, 2022, 258 (1), pp. 1 - 3 | |
dc.identifier.issn | 0022-3417 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5435 | |
dc.identifier.eissn | 1096-9896 | |
dc.identifier.eissn | 1096-9896 | |
dc.identifier.doi | 10.1002/path.5973 | |
dc.description.abstract | The ARID1A tumour suppressor protein is a component of the SWI/SNF chromatin remodelling complex, which is mutated in approximately 20% of all human cancers. ARID1A mutational status is considered to hold prognostic significance in a range of solid malignancies, yet in endometriosis-related ovarian carcinomas there has been a lack of clarity of its prognostic role. Moreover, the relationship between ARID1A status and immune infiltrate is also poorly understood. In a recent issue of The Journal of Pathology, a large comprehensive study by Heinze, Nazeran et al addressed these areas by reviewing 1,623 endometriosis-associated ovarian carcinomas and correlating ARID1A status using standardised immunohistochemistry to infer mutation status, with comprehensive clinicopathological features, mismatch repair status and CD8+ tumour infiltrating lymphocytes. The study definitively showed that ARID1A status does not provide any independent prognostic value in endometriosis-associated ovarian carcinomas. ARID1A loss was, however, shown to be associated with mismatch repair deficiency and increased CD8+ tumour infiltrating lymphocytes in endometrioid ovarian carcinoma, which may be relevant for future studies. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. | |
dc.format | Print-Electronic | |
dc.format.extent | 1 - 3 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.relation.ispartof | Journal of Pathology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | ARID1A | |
dc.subject | CD8 tumour infiltrating lymphocytes | |
dc.subject | biomarker | |
dc.subject | endometriosis-associated ovarian carcinomas | |
dc.subject | mismatch repair deficiency | |
dc.subject | Carcinoma, Endometrioid | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Endometriosis | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Mutation | |
dc.subject | Nuclear Proteins | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Transcription Factors | |
dc.title | Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis-related ovarian cancers‡. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-05-30 | |
dc.date.updated | 2022-09-06T15:07:54Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1002/path.5973 | |
rioxxterms.licenseref.startdate | 2022-06-29 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35647895 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/14/15 Starting Cohort | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1002/path.5973 | |
pubs.volume | 258 | |
icr.researchteam | Functional Genomics | |
dc.contributor.icrauthor | Natrajan, Rachael | |
icr.provenance | Deposited by Mr Arek Surman on 2022-09-06. Deposit type is initial. No. of files: 1. Files: The Journal of Pathology - 2022 - Khalique - Definitive study shows no association between ARID1A mutation status and.pdf | |