dc.contributor.author | Kousi, E | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Miah, A | |
dc.contributor.author | Orton, M | |
dc.contributor.author | Haas, R | |
dc.contributor.author | Thway, K | |
dc.contributor.author | Hopkinson, G | |
dc.contributor.author | Zaidi, S | |
dc.contributor.author | Smith, M | |
dc.contributor.author | Barquin, E | |
dc.contributor.author | Moskovic, E | |
dc.contributor.author | Fotiadis, N | |
dc.contributor.author | Strauss, D | |
dc.contributor.author | Hayes, A | |
dc.contributor.author | Schmidt, MA | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-09-13T13:52:32Z | |
dc.date.available | 2022-09-13T13:52:32Z | |
dc.date.issued | 2021-10-01 | |
dc.identifier | ARTN 20210310 | |
dc.identifier.citation | British Journal of Radiology, 2021, 94 (1126), pp. 20210310 - | |
dc.identifier.issn | 0007-1285 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5456 | |
dc.identifier.eissn | 1748-880X | |
dc.identifier.eissn | 1748-880X | |
dc.identifier.doi | 10.1259/bjr.20210310 | |
dc.description.abstract | OBJECTIVES: Myxoid liposarcomas (MLS) show enhanced response to radiotherapy due to their distinctive vascular pattern and therefore could be effectively treated with lower radiation doses. This is a descriptive study to explore the use of functional MRI to identify response in a uniform cohort of MLS patients treated with reduced dose radiotherapy. METHODS: 10 patients with MLS were imaged pre-, during, and post-radiotherapy receiving reduced dose radiotherapy and the response to treatment was histopathologically assessed post-radiotherapy. Apparent diffusion coefficient (ADC), T2* relaxation time, volume transfer constant (Ktrans), initial area under the gadolinium curve over 60 s (IAUGC60) and (Gd) were estimated for a central tumour volume. RESULTS: All parameters showed large inter- and intrasubject variabilities. Pre-treatment (Gd), IAUGC60 and Ktrans were significantly different between responders and non-responders. Post-radiotherapy reductions from baseline were demonstrated for T2*, (Gd), IAUGC60 and Ktrans for responders. No statistically significant ADC differences were demonstrated between the two response groups. Significantly greater early tumour volume reductions were observed for responders. CONCLUSIONS: MLS are heterogenous lesions, characterised by a slow gradual contrast-agent uptake. Pre-treatment vascular parameters, early changes to tumour volume, vascular parameters and T2* have potential in identifying response to treatment. The delayed (Gd) is a suitable descriptive parameter, relying simply on T1 measurements. Volume changes precede changes in MLS functionality and could be used to identify early response. ADVANCES IN KNOWLEDGE: MLS are are characterised by slow gradual contrast-agent uptake. Measurement of the delayed contrast-agent uptake (Gd) is simple to implement and able to discriminate response. | |
dc.format | Print | |
dc.format.extent | 20210310 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.relation.ispartof | British Journal of Radiology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adult | |
dc.subject | Contrast Media | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Liposarcoma, Myxoid | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Pilot Projects | |
dc.subject | Radiotherapy Dosage | |
dc.subject | Radiotherapy, Conformal | |
dc.subject | Radiotherapy, Intensity-Modulated | |
dc.subject | Tumor Burden | |
dc.title | Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-09-21 | |
dc.date.updated | 2022-09-13T13:51:31Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1259/bjr.20210310 | |
rioxxterms.licenseref.startdate | 2021-10-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34545764 | |
pubs.issue | 1126 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1259/bjr.20210310 | |
pubs.volume | 94 | |
icr.researchteam | Translational Sarcoma, Melanoma and Rare Tumour Surgery | |
icr.researchteam | Sarcoma&Melanoma Surgery | |
dc.contributor.icrauthor | Smith, Myles | |
icr.provenance | Deposited by Mr Arek Surman on 2022-09-13. Deposit type is initial. No. of files: 1. Files: Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas.pdf | |