dc.contributor.author | Bernier-Latmani, J | |
dc.contributor.author | Mauri, C | |
dc.contributor.author | Marcone, R | |
dc.contributor.author | Renevey, F | |
dc.contributor.author | Durot, S | |
dc.contributor.author | He, L | |
dc.contributor.author | Vanlandewijck, M | |
dc.contributor.author | Maclachlan, C | |
dc.contributor.author | Davanture, S | |
dc.contributor.author | Zamboni, N | |
dc.contributor.author | Knott, GW | |
dc.contributor.author | Luther, SA | |
dc.contributor.author | Betsholtz, C | |
dc.contributor.author | Delorenzi, M | |
dc.contributor.author | Brisken, C | |
dc.contributor.author | Petrova, TV | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-09-14T08:46:23Z | |
dc.date.available | 2022-09-14T08:46:23Z | |
dc.date.issued | 2022-07-09 | |
dc.identifier | ARTN 3983 | |
dc.identifier | 10.1038/s41467-022-31571-2 | |
dc.identifier.citation | Nature Communications, 2022, 13 (1), pp. 3983 - | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5468 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-022-31571-2 | |
dc.description.abstract | The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial organization of small intestinal villus tip blood vessels: their exterior, epithelial-facing side is fenestrated, while the side facing the villus stroma is non-fenestrated, covered by pericytes and harbors endothelial nuclei. Such organization optimizes the absorption process, however the molecular mechanisms maintaining this highly specialized structure remain unclear. Here we report that perivascular LGR5+ villus tip telocytes (VTTs) are necessary for maintenance of villus tip endothelial cell polarization and fenestration by sequestering VEGFA signaling. Mechanistically, unique VTT expression of the protease ADAMTS18 is necessary for VEGFA signaling sequestration through limiting fibronectin accumulation. Therefore, we propose a model in which LGR5+ ADAMTS18+ telocytes are necessary to maintain a "just-right" level and location of VEGFA signaling in intestinal villus blood vasculature to ensure on one hand the presence of sufficient endothelial fenestrae, while avoiding excessive leakiness of the vessels and destabilization of villus tip epithelial structures. | |
dc.format | Electronic | |
dc.format.extent | 3983 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | Nature Communications | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Duodenum | |
dc.subject | Intestinal Mucosa | |
dc.subject | Intestines | |
dc.subject | Nutrients | |
dc.subject | Telocytes | |
dc.title | ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-06-21 | |
dc.date.updated | 2022-09-14T08:45:39Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41467-022-31571-2 | |
rioxxterms.licenseref.startdate | 2022-07-09 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35810168 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41467-022-31571-2 | |
pubs.volume | 13 | |
icr.researchteam | Endocrine control mechans | |
dc.contributor.icrauthor | Brisken, Cathrin | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Dr Elena Lopez Knowles) on 2022-09-14. Deposit type is initial. No. of files: 1. Files: ADAMTS18sup+sup villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing int.pdf | |