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dc.contributor.authorKaza, E
dc.contributor.authorDunlop, A
dc.contributor.authorPanek, R
dc.contributor.authorCollins, DJ
dc.contributor.authorOrton, M
dc.contributor.authorSymonds-Tayler, R
dc.contributor.authorMcQuaid, D
dc.contributor.authorScurr, E
dc.contributor.authorHansen, V
dc.contributor.authorLeach, MO
dc.date.accessioned2017-04-03T09:59:09Z
dc.date.issued2017-03-01
dc.identifier.citationJournal of applied clinical medical physics, 2017, 18 (2), pp. 154 - 162
dc.identifier.issn1526-9914
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/546
dc.identifier.eissn1526-9914
dc.identifier.doi10.1002/acm2.12034
dc.description.abstractAn Active Breathing Coordinator (ABC) can be employed to induce breath-holds during CT imaging and radiotherapy of lung, breast and liver cancer, and recently during lung cancer MRI. The apparatus measures and controls respiratory volume, hence subject lung volume reproducibility is its principal measure of effectiveness. To assess ABC control quality, the intra-session reproducibility of ABC-induced lung volumes was evaluated and compared with that reached by applying the clinical standard of operator-guided self-sustained breath-holds on healthy volunteers during MRI. Inter-session reproducibility was investigated by repeating ABC-controlled breath-holds on a second visit. Additionally, lung volume agreement with ABC devices used with different imaging modalities in the same institution (MR, CT), or for a breast trial treatment, was assessed. Lung volumes were derived from three-dimensional (3D) T1-weighted MRI datasets by three observers employing semiautomatic lung delineation on a radiotherapy treatment planning system. Inter-observer variability was less than 6% of the delineated lung volumes. Lung volume agreement between the different conditions over all subjects was investigated using descriptive statistics. The ABC equipment dedicated for MR application exhibited good intra-session and inter-session lung volume reproducibility (1.8% and 3% lung volume variability on average, respectively). MR-assessed lung volumes were similar using different ABC equipment dedicated to MR, CT, or breast radiotherapy. Overall, lung volumes controlled by the same or different ABC devices agreed better than with self-controlled breath-holds, as suggested by the average ABC variation of 1.8% of the measured lung volumes (99 mL), compared to the 4.1% (226 mL) variability observed on average with self-sustained breath-holding.
dc.formatPrint-Electronic
dc.format.extent154 - 162
dc.languageeng
dc.language.isoeng
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectLung
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectMagnetic Resonance Imaging
dc.subjectRadiotherapy Dosage
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectReproducibility of Results
dc.subjectRespiration
dc.subjectMovement
dc.subjectImage Processing, Computer-Assisted
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectRadiotherapy, Intensity-Modulated
dc.subjectRespiratory-Gated Imaging Techniques
dc.subjectPatient Positioning
dc.subjectBreath Holding
dc.subjectHealthy Volunteers
dc.titleLung volume reproducibility under ABC control and self-sustained breath-holding.
dc.typeJournal Article
dcterms.dateAccepted2016-10-09
rioxxterms.versionofrecord10.1002/acm2.12034
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of applied clinical medical physics
pubs.issue2
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume18
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonance
dc.contributor.icrauthorCollins, David
dc.contributor.icrauthorLeach, Martin


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