dc.contributor.author | Aouad, P | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | De Martino, F | |
dc.contributor.author | Stibolt, C | |
dc.contributor.author | Ali, S | |
dc.contributor.author | Ambrosini, G | |
dc.contributor.author | Mani, SA | |
dc.contributor.author | Maggs, K | |
dc.contributor.author | Quinn, HM | |
dc.contributor.author | Sflomos, G | |
dc.contributor.author | Brisken, C | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-11-16T15:21:23Z | |
dc.date.available | 2022-11-16T15:21:23Z | |
dc.date.issued | 2022-08-25 | |
dc.identifier | ARTN 4975 | |
dc.identifier | 10.1038/s41467-022-32523-6 | |
dc.identifier.citation | Nature Communications, 2022, 13 (1), pp. 4975 - | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5562 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-022-32523-6 | |
dc.description.abstract | More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive due to lack of adequate in vivo models. We compare intraductal xenografts of ER+ and triple-negative (TN) BC cells and demonstrate that disseminated TNBC cells proliferate similarly as TNBC cells at the primary site whereas disseminated ER+ BC cells proliferate slower, they decrease CDH1 and increase ZEB1,2 expressions, and exhibit characteristics of epithelial-mesenchymal plasticity (EMP) and dormancy. Forced E-cadherin expression overcomes ER+ BC dormancy. Cytokine signalings are enriched in more active versus inactive disseminated tumour cells, suggesting microenvironmental triggers for awakening. We conclude that intraductal xenografts model ER + BC dormancy and reveal that EMP is essential for the generation of a dormant cell state and that targeting exit from EMP has therapeutic potential. | |
dc.format | Electronic | |
dc.format.extent | 4975 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Nature Communications | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Breast Neoplasms | |
dc.subject | Cell Line, Tumor | |
dc.subject | Epithelial-Mesenchymal Transition | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Receptors, Estrogen | |
dc.subject | Triple Negative Breast Neoplasms | |
dc.title | Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-08-02 | |
dc.date.updated | 2022-11-16T15:20:22Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s41467-022-32523-6 | en_US |
rioxxterms.licenseref.startdate | 2022-08-25 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36008376 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41467-022-32523-6 | |
pubs.volume | 13 | |
icr.researchteam | Endocrine control mechans | en_US |
dc.contributor.icrauthor | Brisken, Cathrin | |
icr.provenance | Deposited by Mr Arek Surman on 2022-11-16. Deposit type is initial. No. of files: 1. Files: Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion d.pdf | |