dc.contributor.author | Rothermundt, C | |
dc.contributor.author | Andreou, D | |
dc.contributor.author | Blay, J-Y | |
dc.contributor.author | Brodowicz, T | |
dc.contributor.author | Desar, IME | |
dc.contributor.author | Dileo, P | |
dc.contributor.author | Gelderblom, H | |
dc.contributor.author | Haas, R | |
dc.contributor.author | Jakob, J | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Judson, I | |
dc.contributor.author | Kunz, WG | |
dc.contributor.author | Liegl-Atzwanger, B | |
dc.contributor.author | Lindner, LH | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Miah, AB | |
dc.contributor.author | Reichardt, P | |
dc.contributor.author | Szkandera, J | |
dc.contributor.author | van der Graaf, WTA | |
dc.contributor.author | van Houdt, WJ | |
dc.contributor.author | Wardelmann, E | |
dc.contributor.author | Hofer, S | |
dc.contributor.author | Writing committee on behalf of CSSS panellists, | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-02-06T16:28:35Z | |
dc.date.available | 2023-02-06T16:28:35Z | |
dc.date.issued | 2022-11-16 | |
dc.identifier | S0959-8049(22)01344-2 | |
dc.identifier.citation | European Journal of Cancer, 2022, 180 pp. 158 - 179 | |
dc.identifier.issn | 0959-8049 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5677 | |
dc.identifier.eissn | 1879-0852 | |
dc.identifier.eissn | 1879-0852 | |
dc.identifier.doi | 10.1016/j.ejca.2022.11.008 | |
dc.description.abstract | BACKGROUND: Owing to the rarity and heterogeneity in biology and presentation, there are multiple areas in the diagnosis, treatment and follow-up of soft tissue sarcoma (STS), with no, low-level or conflicting evidence. METHODS: During the first Consensus Conference on the State of Science in Sarcoma (CSSS), we used a modified Delphi process to identify areas of controversy in the field of sarcoma, to name topics with limited evidence-based data in which a scientific and knowledge gap may remain and a consensus statement will help to guide patient management. We determined scientific questions which need to be addressed in the future in order to generate evidence and to inform physicians and caregivers in daily clinical practice in order to improve the outcomes of patients with sarcoma. We conducted a vote on STS key questions and controversies prior to the CSSS meeting, which took place in May 2022. RESULTS: Sixty-two European sarcoma experts participated in the survey. Sixteen strong consensus (≥95%) items were identified by the experts, as well as 30 items with a ≥75% consensus on diagnostic and therapeutic questions. Ultimately, many controversy topics remained without consensus. CONCLUSIONS: In this manuscript, we summarise the voting results and the discussion during the CSSS meeting. Future scientific questions, priorities for clinical trials, registries, quality assurance, and action by stakeholders are proposed. Platforms and partnerships can support innovative approaches to improve management and clinical research in STS. | |
dc.format | Print-Electronic | |
dc.format.extent | 158 - 179 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCI LTD | |
dc.relation.ispartof | European Journal of Cancer | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Consensus | |
dc.subject | Diagnosis | |
dc.subject | Imaging | |
dc.subject | Multimodal treatment | |
dc.subject | Peri-operative management | |
dc.subject | Policy | |
dc.subject | Soft tissue sarcoma | |
dc.subject | Surveillance | |
dc.subject | Treatment of advanced disease | |
dc.title | Controversies in the management of patients with soft tissue sarcoma: Recommendations of the Conference on State of Science in Sarcoma 2022. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-11-04 | |
dc.date.updated | 2023-02-02T16:06:36Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.ejca.2022.11.008 | |
rioxxterms.licenseref.startdate | 2022-11-16 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36599184 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular and Systems Oncology | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.ejca.2022.11.008 | |
pubs.volume | 180 | |
icr.researchteam | Sarcoma Clinical Trials | |
dc.contributor.icrauthor | Jones, Robin | |
dc.contributor.icrauthor | Judson, Ian | |
dc.contributor.icrauthor | Messiou, Christina | |
icr.provenance | Deposited by Mr Arek Surman on 2023-02-02. Deposit type is initial. No. of files: 1. Files: 1-s2.0-S0959804922013442-main.pdf | |