Controversies in the management of patients with soft tissue sarcoma: Recommendations of the Conference on State of Science in Sarcoma 2022.
Date
2022-11-16Author
Rothermundt, C
Andreou, D
Blay, J-Y
Brodowicz, T
Desar, IME
Dileo, P
Gelderblom, H
Haas, R
Jakob, J
Jones, RL
Judson, I
Kunz, WG
Liegl-Atzwanger, B
Lindner, LH
Messiou, C
Miah, AB
Reichardt, P
Szkandera, J
van der Graaf, WTA
van Houdt, WJ
Wardelmann, E
Hofer, S
Writing committee on behalf of CSSS panellists,
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: Owing to the rarity and heterogeneity in biology and presentation, there are multiple areas in the diagnosis, treatment and follow-up of soft tissue sarcoma (STS), with no, low-level or conflicting evidence. METHODS: During the first Consensus Conference on the State of Science in Sarcoma (CSSS), we used a modified Delphi process to identify areas of controversy in the field of sarcoma, to name topics with limited evidence-based data in which a scientific and knowledge gap may remain and a consensus statement will help to guide patient management. We determined scientific questions which need to be addressed in the future in order to generate evidence and to inform physicians and caregivers in daily clinical practice in order to improve the outcomes of patients with sarcoma. We conducted a vote on STS key questions and controversies prior to the CSSS meeting, which took place in May 2022. RESULTS: Sixty-two European sarcoma experts participated in the survey. Sixteen strong consensus (≥95%) items were identified by the experts, as well as 30 items with a ≥75% consensus on diagnostic and therapeutic questions. Ultimately, many controversy topics remained without consensus. CONCLUSIONS: In this manuscript, we summarise the voting results and the discussion during the CSSS meeting. Future scientific questions, priorities for clinical trials, registries, quality assurance, and action by stakeholders are proposed. Platforms and partnerships can support innovative approaches to improve management and clinical research in STS.
Collections
Subject
Consensus
Diagnosis
Imaging
Multimodal treatment
Peri-operative management
Policy
Soft tissue sarcoma
Surveillance
Treatment of advanced disease
Research team
Sarcoma Clinical Trials
Language
eng
Date accepted
2022-11-04
License start date
2022-11-16
Citation
European Journal of Cancer, 2022, 180 pp. 158 - 179
Publisher
ELSEVIER SCI LTD