dc.contributor.author | Kang, E-Y | |
dc.contributor.author | Weir, A | |
dc.contributor.author | Meagher, NS | |
dc.contributor.author | Farrington, K | |
dc.contributor.author | Nelson, GS | |
dc.contributor.author | Ghatage, P | |
dc.contributor.author | Lee, C-H | |
dc.contributor.author | Riggan, MJ | |
dc.contributor.author | Bolithon, A | |
dc.contributor.author | Popovic, G | |
dc.contributor.author | Leung, B | |
dc.contributor.author | Tang, K | |
dc.contributor.author | Lambie, N | |
dc.contributor.author | Millstein, J | |
dc.contributor.author | Alsop, J | |
dc.contributor.author | Anglesio, MS | |
dc.contributor.author | Ataseven, B | |
dc.contributor.author | Barlow, E | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Berger, J | |
dc.contributor.author | Bisinotto, C | |
dc.contributor.author | Bösmüller, H | |
dc.contributor.author | Boros, J | |
dc.contributor.author | Brand, AH | |
dc.contributor.author | Brooks-Wilson, A | |
dc.contributor.author | Brucker, SY | |
dc.contributor.author | Carney, ME | |
dc.contributor.author | Casablanca, Y | |
dc.contributor.author | Cazorla-Jiménez, A | |
dc.contributor.author | Cohen, PA | |
dc.contributor.author | Conrads, TP | |
dc.contributor.author | Cook, LS | |
dc.contributor.author | Coulson, P | |
dc.contributor.author | Courtney-Brooks, M | |
dc.contributor.author | Cramer, DW | |
dc.contributor.author | Crowe, P | |
dc.contributor.author | Cunningham, JM | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Darcy, KM | |
dc.contributor.author | El-Bahrawy, MA | |
dc.contributor.author | Elishaev, E | |
dc.contributor.author | Erber, R | |
dc.contributor.author | Farrell, R | |
dc.contributor.author | Fereday, S | |
dc.contributor.author | Fischer, A | |
dc.contributor.author | García, MJ | |
dc.contributor.author | Gayther, SA | |
dc.contributor.author | Gentry-Maharaj, A | |
dc.contributor.author | Gilks, CB | |
dc.contributor.author | AOCS Group, | |
dc.contributor.author | Grube, M | |
dc.contributor.author | Harnett, PR | |
dc.contributor.author | Harrington, SP | |
dc.contributor.author | Harter, P | |
dc.contributor.author | Hartmann, A | |
dc.contributor.author | Hecht, JL | |
dc.contributor.author | Heikaus, S | |
dc.contributor.author | Hein, A | |
dc.contributor.author | Heitz, F | |
dc.contributor.author | Hendley, J | |
dc.contributor.author | Hernandez, BY | |
dc.contributor.author | Polo, SH | |
dc.contributor.author | Heublein, S | |
dc.contributor.author | Hirasawa, A | |
dc.contributor.author | Høgdall, E | |
dc.contributor.author | Høgdall, CK | |
dc.contributor.author | Horlings, HM | |
dc.contributor.author | Huntsman, DG | |
dc.contributor.author | Huzarski, T | |
dc.contributor.author | Jewell, A | |
dc.contributor.author | Jimenez-Linan, M | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Kaufmann, SH | |
dc.contributor.author | Kennedy, CJ | |
dc.contributor.author | Khabele, D | |
dc.contributor.author | Kommoss, FKF | |
dc.contributor.author | Kruitwagen, RFPM | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le, ND | |
dc.contributor.author | Lener, M | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Leung, Y | |
dc.contributor.author | Linder, A | |
dc.contributor.author | Loverix, L | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Madan, R | |
dc.contributor.author | Maxwell, GL | |
dc.contributor.author | Modugno, F | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Olawaiye, A | |
dc.contributor.author | Olbrecht, S | |
dc.contributor.author | Orsulic, S | |
dc.contributor.author | Palacios, J | |
dc.contributor.author | Pearce, CL | |
dc.contributor.author | Pike, MC | |
dc.contributor.author | Quinn, CM | |
dc.contributor.author | Mohan, GR | |
dc.contributor.author | Rodríguez-Antona, C | |
dc.contributor.author | Ruebner, M | |
dc.contributor.author | Ryan, A | |
dc.contributor.author | Salfinger, SG | |
dc.contributor.author | Sasamoto, N | |
dc.contributor.author | Schildkraut, JM | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Sharma, R | |
dc.contributor.author | Shvetsov, YB | |
dc.contributor.author | Singh, N | |
dc.contributor.author | Sonke, GS | |
dc.contributor.author | Steele, L | |
dc.contributor.author | Stewart, CJR | |
dc.contributor.author | Sundfeldt, K | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Talhouk, A | |
dc.contributor.author | Tan, A | |
dc.contributor.author | Taylor, SE | |
dc.contributor.author | Terry, KL | |
dc.contributor.author | Tołoczko, A | |
dc.contributor.author | Traficante, N | |
dc.contributor.author | Van de Vijver, KK | |
dc.contributor.author | van der Aa, MA | |
dc.contributor.author | Van Gorp, T | |
dc.contributor.author | Van Nieuwenhuysen, E | |
dc.contributor.author | van-Wagensveld, L | |
dc.contributor.author | Vergote, I | |
dc.contributor.author | Vierkant, RA | |
dc.contributor.author | Wang, C | |
dc.contributor.author | Wilkens, LR | |
dc.contributor.author | Winham, SJ | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Berchuck, A | |
dc.contributor.author | Candido Dos Reis, FJ | |
dc.contributor.author | DeFazio, A | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Goode, EL | |
dc.contributor.author | Goodman, MT | |
dc.contributor.author | Gronwald, J | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Kommoss, S | |
dc.contributor.author | Menon, U | |
dc.contributor.author | Sinn, H-P | |
dc.contributor.author | Staebler, A | |
dc.contributor.author | Brenton, JD | |
dc.contributor.author | Bowtell, DD | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Ramus, SJ | |
dc.contributor.author | Köbel, M | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-04-12T09:57:39Z | |
dc.date.available | 2023-04-12T09:57:39Z | |
dc.date.issued | 2023-03-01 | |
dc.identifier.citation | Cancer, 2023, 129 (5), pp. 697 - 713 | |
dc.identifier.issn | 0008-543X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5741 | |
dc.identifier.eissn | 1097-0142 | |
dc.identifier.eissn | 1097-0142 | |
dc.identifier.doi | 10.1002/cncr.34582 | |
dc.description.abstract | BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC. METHODS: Within the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated. RESULTS: High-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss. CONCLUSION: This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC. | |
dc.format | Print-Electronic | |
dc.format.extent | 697 - 713 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.relation.ispartof | Cancer | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | CCNE1 amplification | |
dc.subject | cyclin E1 expression | |
dc.subject | high-grade serous carcinoma | |
dc.subject | ovarian cancer | |
dc.subject | prognosis | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Transcription Factors | |
dc.subject | Carcinoma | |
dc.subject | RNA, Messenger | |
dc.subject | Cystadenocarcinoma, Serous | |
dc.subject | Oncogene Proteins | |
dc.subject | Cyclin E | |
dc.title | CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-09-30 | |
dc.date.updated | 2023-04-12T09:56:52Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1002/cncr.34582 | |
rioxxterms.licenseref.startdate | 2023-03-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36572991 | |
pubs.issue | 5 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1002/cncr.34582 | |
pubs.volume | 129 | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
icr.provenance | Deposited by Mr Arek Surman on 2023-04-12. Deposit type is initial. No. of files: 1. Files: Cancer - 2022 - Kang - CCNE1 and survival of patients with tubo‐ovarian high‐grade serous carcinoma An Ovarian Tumor.pdf | |