dc.contributor.author | Yeung, J | |
dc.contributor.author | Fotiadis, N | |
dc.contributor.author | Diamantopoulos, A | |
dc.contributor.author | Tutt, A | |
dc.contributor.author | Roxanis, I | |
dc.contributor.author | Bandula, S | |
dc.date.accessioned | 2023-04-12T13:02:27Z | |
dc.date.available | 2023-04-12T13:02:27Z | |
dc.date.issued | 2023-03-01 | |
dc.identifier.citation | Journal of Vascular and Interventional Radiology, 2023, | |
dc.identifier.issn | 1051-0443 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5752 | |
dc.identifier.doi | 10.1016/j.jvir.2023.03.012 | |
dc.description.abstract | The discovery of increasing numbers of actionable molecular and gene targets for cancer treatment has driven the demand for tissue sampling for next-generation sequencing (NGS). Requirements for sequencing can be very specific, and inadequate sampling leads to delays in management and decision making. It is important that interventional radiologists are aware of NGS technologies and their common applications and be cognizant of the factors that contribute to successful sample sequencing. This review summarizes the fundamentals of cancer tissue collection and processing for NGS. It elaborates on sequencing technologies and their applications with the aim of providing readers with a working understanding that can enhance their clinical practice. It then describes imaging, tumor, biopsy, and sample collection factors that improve the chances of NGS success. Finally, it discusses future practice, highlighting the problem of undersampling in both clinical and research settings and the opportunities within interventional radiology to address this. | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Journal of Vascular and Interventional Radiology | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Next-Generation Sequencing and Image-Guided Tissue Sampling: A Primer for Interventional Radiologists. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-03-18 | |
dc.date.updated | 2023-04-06T13:09:41Z | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1016/j.jvir.2023.03.012 | |
rioxxterms.licenseref.startdate | 2023-03-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Target Validation and DNA Damage Response | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/20/21 Starting Cohort | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.jvir.2023.03.012 | |
icr.researchteam | Target Vali & DNA Dam Res | |
icr.researchteam | Directorate Breast Canc | |
dc.contributor.icrauthor | Yeung, Chit Sum Jason | |
dc.contributor.icrauthor | Tutt, Andrew | |
icr.provenance | Deposited by Dr Jason Yeung on 2023-04-06. Deposit type is initial. No. of files: 1. Files: Manuscript March 23 clean final.pdf | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Dr Jason Yeung) on 2023-05-15. Deposit type is subsequent. No. of files: 1. Files: 1-s2.0-S1051044323002245-main.pdf | |
icr.provenance | Deposited by Dr Jason Yeung on 2023-04-06. Deposit type is subsequent. No. of files: 9. Files: Manuscript March 23 clean final.pdf; Supplementary material glossary.pdf; Figure 2.pdf; Figure 3.pdf; Table 1.pdf; Table 2.pdf; Table 3.pdf; Table 4.pdf; Figure 1.pdf | |