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dc.contributor.authorHawer, H
dc.contributor.authorHammermeister, A
dc.contributor.authorRavichandran, KE
dc.contributor.authorGlatt, S
dc.contributor.authorSchaffrath, R
dc.contributor.authorKlassen, R
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-05-19T10:08:56Z
dc.date.available2023-05-19T10:08:56Z
dc.date.issued2018-12-28
dc.identifierARTN 19
dc.identifiergenes10010019
dc.identifier.citationGenes, 2018, 10 (1), pp. E19 -en_US
dc.identifier.issn2073-4425
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5795
dc.identifier.eissn2073-4425
dc.identifier.eissn2073-4425
dc.identifier.doi10.3390/genes10010019
dc.description.abstractTransfer RNA (tRNA) is subject to a multitude of posttranscriptional modifications which can profoundly impact its functionality as the essential adaptor molecule in messenger RNA (mRNA) translation. Therefore, dynamic regulation of tRNA modification in response to environmental changes can tune the efficiency of gene expression in concert with the emerging epitranscriptomic mRNA regulators. Several of the tRNA modifications are required to prevent human diseases and are particularly important for proper development and generation of neurons. In addition to the positive role of different tRNA modifications in prevention of neurodegeneration, certain cancer types upregulate tRNA modification genes to sustain cancer cell gene expression and metastasis. Multiple associations of defects in genes encoding subunits of the tRNA modifier complex Elongator with human disease highlight the importance of proper anticodon wobble uridine modifications (xm⁵U34) for health. Elongator functionality requires communication with accessory proteins and dynamic phosphorylation, providing regulatory control of its function. Here, we summarized recent insights into molecular functions of the complex and the role of Elongator dependent tRNA modification in human disease.
dc.formatElectronic
dc.format.extentE19 -
dc.languageeng
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofGenes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectElongator
dc.subjectU34
dc.subjectcancer
dc.subjectdiphthamide
dc.subjectepitranscriptomics
dc.subjectneurodegeneration
dc.subjecttRNA
dc.subjecttRNA modification
dc.subjectwobble uridine modifications
dc.titleRoles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-12-20
dc.date.updated2023-05-19T09:51:02Z
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.3390/genes10010019en_US
rioxxterms.licenseref.startdate2018-12-28
rioxxterms.typeJournal Article/Reviewen_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30597914
pubs.issue1
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Structural Biology of Cell Signalling
pubs.publication-statusPublished online
pubs.publisher-urlhttp://dx.doi.org/10.3390/genes10010019
pubs.volume10
icr.provenanceDeposited by Mr Keerthiraju Ethiraju Ravichandran on 2023-05-19. Deposit type is initial. No. of files: 1. Files: Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer. .pdf


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