Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours.
Date
2020-08-03Author
Kristeleit, R
Evans, J
Molife, LR
Tunariu, N
Shaw, H
Slater, S
Haris, NRM
Brown, NF
Forster, MD
Diamantis, N
Rulach, R
Greystoke, A
Asghar, U
Rata, M
Anderson, S
Bachmann, F
Hannah, A
Kaindl, T
Lane, HA
Larger, PJ
Schmitt-Hoffmann, A
Engelhardt, M
Tzankov, A
Plummer, R
Lopez, J
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: BAL101553 (lisavanbulin), the lysine prodrug of BAL27862 (avanbulin), exhibits broad anti-proliferative activity in human cancer models refractory to clinically relevant microtubule-targeting agents. METHODS: This two-part, open-label, phase 1/2a study aimed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of 2-h infusion of BAL101553 in adults with advanced or recurrent solid tumours. The MTD was determined using a modified accelerated titration design in phase I. Patients received BAL101553 at the MTD and at lower doses in the phase 2a expansion to characterise safety and efficacy and to determine the recommended phase 2 dose (RP2D). RESULTS: Seventy-three patients received BAL101553 at doses of 15-80 mg/m2 (phase 1, n = 24; phase 2a, n = 49). The MTD was 60 mg/m2; DLTs observed at doses ≥60 mg/m2 were reversible Grade 2-3 gait disturbance with Grade 2 peripheral sensory neuropathy. In phase 2a, asymptomatic myocardial injury was observed at doses ≥45 mg/m2. The RP2D for 2-h intravenous infusion was 30 mg/m2. The overall disease control rate was 26.3% in the efficacy population. CONCLUSIONS: The RP2D for 2-h infusion of BAL101553 was well tolerated. Dose-limiting neurological and myocardial side effects were consistent with the agent's vascular-disrupting properties. CLINICAL TRIAL REGISTRATION: EudraCT: 2010-024237-23.
Collections
Subject
Adult
Aged
Aged, 80 and over
Benzimidazoles
Disease Progression
Female
Humans
Infusions, Intravenous
M Phase Cell Cycle Checkpoints
Male
Maximum Tolerated Dose
Middle Aged
Neoplasms
Oxadiazoles
Prodrugs
Spindle Apparatus
United Kingdom
Research team
Early Phase Drug Develop
Language
eng
Date accepted
2020-07-16
License start date
2020-08-03
Citation
British Journal of Cancer, 2020, 123 (9), pp. 1360 - 1369
Publisher
SPRINGERNATURE