dc.contributor.author | Gibson, SV | |
dc.contributor.author | Tomas Bort, E | |
dc.contributor.author | Rodríguez-Fernández, L | |
dc.contributor.author | Allen, MD | |
dc.contributor.author | Gomm, JJ | |
dc.contributor.author | Goulding, I | |
dc.contributor.author | Auf dem Keller, U | |
dc.contributor.author | Agnoletto, A | |
dc.contributor.author | Brisken, C | |
dc.contributor.author | Peck, B | |
dc.contributor.author | Cameron, AJ | |
dc.contributor.author | Marshall, JF | |
dc.contributor.author | Jones, JL | |
dc.contributor.author | Carter, EP | |
dc.contributor.author | Grose, RP | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-05-30T12:58:10Z | |
dc.date.available | 2023-05-30T12:58:10Z | |
dc.date.issued | 2023-03-02 | |
dc.identifier | ARTN 9 | |
dc.identifier | 10.1038/s41523-023-00513-6 | |
dc.identifier.citation | npj Breast Cancer, 2023, 9 (1), pp. 9 - | |
dc.identifier.issn | 2374-4677 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5818 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.doi | 10.1038/s41523-023-00513-6 | |
dc.description.abstract | Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus presents a pressing issue in DCIS management. To understand the role of the normally tumour suppressive myoepithelial cell in disease progression we present a 3D in vitro model incorporating both luminal and myoepithelial cells in physiomimetic conditions. We demonstrate that DCIS-associated myoepithelial cells promote striking myoepithelial-led invasion of luminal cells, mediated by the collagenase MMP13 through a non-canonical TGFβ - EP300 pathway. In vivo, MMP13 expression is associated with stromal invasion in a murine model of DCIS progression and is elevated in myoepithelial cells of clinical high-grade DCIS cases. Our data identify a key role for myoepithelial-derived MMP13 in facilitating DCIS progression and point the way towards a robust marker for risk stratification in DCIS patients. | |
dc.format | Electronic | |
dc.format.extent | 9 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | npj Breast Cancer | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Oncology | |
dc.subject | CARCINOMA IN-SITU | |
dc.subject | GROWTH-FACTOR REQUIREMENTS | |
dc.subject | HUMAN MAMMARY-GLAND | |
dc.subject | COLLAGENASE-3 EXPRESSION | |
dc.subject | ALPHA-V-BETA-6 INTEGRIN | |
dc.subject | TUMOR MICROENVIRONMENT | |
dc.subject | COLLECTIVE INVASION | |
dc.subject | EPITHELIAL-CELLS | |
dc.subject | ACTIVATION | |
dc.subject | DCIS | |
dc.title | TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-02-15 | |
dc.date.updated | 2023-05-30T12:57:39Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41523-023-00513-6 | |
rioxxterms.licenseref.startdate | 2023-03-02 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36864079 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41523-023-00513-6 | |
pubs.volume | 9 | |
icr.researchteam | Endocrine control mechans | |
dc.contributor.icrauthor | Brisken, Cathrin | |
icr.provenance | Deposited by Mr Arek Surman on 2023-05-30. Deposit type is initial. No. of files: 1. Files: TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression.pdf | |