Cytoreductive Nephrectomy in the Tyrosine Kinase Inhibitor Era: A Question That May Never Be Answered.
Renal Cross Channel Group
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Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting very slowly (CARMENA) after 7 yr. Challenges in RCT delivery in uro-oncologic surgery are many. Multiple steps are needed to ensure strong recruitment to trials addressing important urologic cancer questions. Feasibility/pilot studies are key stepping stones towards successful delivery of surgical RCTs.
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Carcinoma, Renal Cell
Cytoreduction Surgical Procedures
Molecular Targeted Therapy
Protein Kinase Inhibitors
Randomized Controlled Trials as Topic
Melanoma and Kidney Cancer
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Eur Urol, 71 (6), pp. 845 - 847