dc.contributor.author | Burns, J | |
dc.contributor.author | Wilding, CP | |
dc.contributor.author | Krasny, L | |
dc.contributor.author | Zhu, X | |
dc.contributor.author | Chadha, M | |
dc.contributor.author | Tam, YB | |
dc.contributor.author | Ps, H | |
dc.contributor.author | Mahalingam, AH | |
dc.contributor.author | Lee, ATJ | |
dc.contributor.author | Arthur, A | |
dc.contributor.author | Guljar, N | |
dc.contributor.author | Perkins, E | |
dc.contributor.author | Pankova, V | |
dc.contributor.author | Jenks, A | |
dc.contributor.author | Djabatey, V | |
dc.contributor.author | Szecsei, C | |
dc.contributor.author | McCarthy, F | |
dc.contributor.author | Ragulan, C | |
dc.contributor.author | Milighetti, M | |
dc.contributor.author | Roumeliotis, TI | |
dc.contributor.author | Crosier, S | |
dc.contributor.author | Finetti, M | |
dc.contributor.author | Choudhary, JS | |
dc.contributor.author | Judson, I | |
dc.contributor.author | Fisher, C | |
dc.contributor.author | Schuster, EF | |
dc.contributor.author | Sadanandam, A | |
dc.contributor.author | Chen, TW | |
dc.contributor.author | Williamson, D | |
dc.contributor.author | Thway, K | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Cheang, MCU | |
dc.contributor.author | Huang, PH | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-07-12T09:04:31Z | |
dc.date.available | 2023-07-12T09:04:31Z | |
dc.date.issued | 2023-06-29 | |
dc.identifier | 3834 | |
dc.identifier | 10.1038/s41467-023-39486-2 | |
dc.identifier.citation | Nature Communications, 2023, 14 (1), pp. 3834 - | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5885 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-023-39486-2 | |
dc.description.abstract | Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within leiomyosarcomas, we identify three proteomic subtypes with distinct myogenesis and immune features, anatomical site distribution and survival outcomes. Characterisation of undifferentiated pleomorphic sarcomas and dedifferentiated liposarcomas with low infiltrating CD3 + T-lymphocyte levels nominates the complement cascade as a candidate immunotherapeutic target. Comparative analysis of proteomic and transcriptomic profiles highlights the proteomic-specific features for optimal risk stratification in angiosarcomas. Finally, we define functional signatures termed Sarcoma Proteomic Modules which transcend histological subtype classification and show that a vesicle transport protein signature is an independent prognostic factor for distant metastasis. Our study highlights the utility of proteomics for identifying molecular subgroups with implications for risk stratification and therapy selection and provides a rich resource for future sarcoma research. | |
dc.format | Electronic | |
dc.format.extent | 3834 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | Nature Communications | |
dc.title | The proteomic landscape of soft tissue sarcomas. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-06-15 | |
dc.date.updated | 2023-07-11T07:52:31Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41467-023-39486-2 | |
rioxxterms.licenseref.startdate | 2023-06-29 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37386008 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular and Systems Oncology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine Therapy Resistance | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/21/22 Starting Cohort | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41467-023-39486-2 | |
pubs.volume | 14 | |
icr.researchteam | Clin Trials & Stats Unit | |
icr.researchteam | Functional Proteomics | |
icr.researchteam | Prote & Metabolomics Fac | |
icr.researchteam | Endocrine Therapy Resist | |
icr.researchteam | Systems - Precision Med | |
icr.researchteam | Mol and Systems Oncology | |
dc.contributor.icrauthor | Wilding, Christopher | |
dc.contributor.icrauthor | Krasny, Lukas | |
dc.contributor.icrauthor | Zhu, Xixuan | |
dc.contributor.icrauthor | Chadha, Madhumeeta | |
dc.contributor.icrauthor | Tam, Yuen Bun | |
dc.contributor.icrauthor | Arthur, Amani | |
dc.contributor.icrauthor | Roumeliotis, Theodoros | |
dc.contributor.icrauthor | Choudhary, Jyoti | |
dc.contributor.icrauthor | Schuster, Eugene | |
dc.contributor.icrauthor | Cheang, Chon | |
dc.contributor.icrauthor | Huang, Paul | |
icr.provenance | Deposited by Dr Gene Schuster on 2023-07-11. Deposit type is initial. No. of files: 1. Files: s41467-023-39486-2.pdf | |