Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Date
2023-08-01Author
Page, DB
Broeckx, G
Jahangir, CA
Verbandt, S
Gupta, RR
Thagaard, J
Khiroya, R
Kos, Z
Abduljabbar, K
Acosta Haab, G
Acs, B
Akturk, G
Almeida, JS
Alvarado-Cabrero, I
Azmoudeh-Ardalan, F
Badve, S
Baharun, NB
Bellolio, ER
Bheemaraju, V
Blenman, KR
Botinelly Mendonça Fujimoto, L
Bouchmaa, N
Burgues, O
Cheang, MCU
Ciompi, F
Cooper, LA
Coosemans, A
Corredor, G
Dantas Portela, FL
Deman, F
Demaria, S
Dudgeon, SN
Elghazawy, M
Ely, S
Fernandez-Martín, C
Fineberg, S
Fox, SB
Gallagher, WM
Giltnane, JM
Gnjatic, S
Gonzalez-Ericsson, PI
Grigoriadis, A
Halama, N
Hanna, MG
Harbhajanka, A
Hardas, A
Hart, SN
Hartman, J
Hewitt, S
Hida, AI
Horlings, HM
Husain, Z
Hytopoulos, E
Irshad, S
Janssen, EA
Kahila, M
Kataoka, TR
Kawaguchi, K
Kharidehal, D
Khramtsov, AI
Kiraz, U
Kirtani, P
Kodach, LL
Korski, K
Kovács, A
Laenkholm, A-V
Lang-Schwarz, C
Larsimont, D
Lennerz, JK
Lerousseau, M
Li, X
Ly, A
Madabhushi, A
Maley, SK
Manur Narasimhamurthy, V
Marks, DK
McDonald, ES
Mehrotra, R
Michiels, S
Minhas, FUAA
Mittal, S
Moore, DA
Mushtaq, S
Nighat, H
Papathomas, T
Penault-Llorca, F
Perera, RD
Pinard, CJ
Pinto-Cardenas, JC
Pruneri, G
Pusztai, L
Rahman, A
Rajpoot, NM
Rapoport, BL
Rau, TT
Reis-Filho, JS
Ribeiro, JM
Rimm, D
Vincent-Salomon, A
Salto-Tellez, M
Saltz, J
Sayed, S
Siziopikou, KP
Sotiriou, C
Stenzinger, A
Sughayer, MA
Sur, D
Symmans, F
Tanaka, S
Taxter, T
Tejpar, S
Teuwen, J
Thompson, EA
Tramm, T
Tran, WT
van der Laak, J
van Diest, PJ
Verghese, GE
Viale, G
Vieth, M
Wahab, N
Walter, T
Waumans, Y
Wen, HY
Yang, W
Yuan, Y
Adams, S
Bartlett, JMS
Loibl, S
Denkert, C
Savas, P
Loi, S
Salgado, R
Specht Stovgaard, E
Type
Journal Article
Metadata
Show full item recordAbstract
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.
Collections
Subject
Immunoscore
TIL
multispectral immunofluorescence
sTIL score
spatial heterogeneity
spatial statistics
tumor infiltrating lymphocytes
Humans
Colonic Neoplasms
Biomarkers
Benchmarking
Lymphocytes, Tumor-Infiltrating
Spatial Analysis
Tumor Microenvironment
Research team
Clin Trials & Stats Unit
Language
eng
Date accepted
2023-06-19
License start date
2023-08-01
Citation
Journal of Pathology, 2023, 260 (5), pp. 514 - 532
Publisher
WILEY