Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.
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Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.
Dose-Response Relationship, Drug
HSP70 Heat-Shock Proteins
Small Molecule Libraries
Medicinal Chemistry 3
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Chemical communications (Cambridge, England), 2017, 53 (37), pp. 5167 - 5170