dc.contributor.author | Ciriello, G | |
dc.contributor.author | Magnani, L | |
dc.contributor.author | Aitken, SJ | |
dc.contributor.author | Akkari, L | |
dc.contributor.author | Behjati, S | |
dc.contributor.author | Hanahan, D | |
dc.contributor.author | Landau, DA | |
dc.contributor.author | Lopez-Bigas, N | |
dc.contributor.author | Lupiáñez, DG | |
dc.contributor.author | Marine, J-C | |
dc.contributor.author | Martin-Villalba, A | |
dc.contributor.author | Natoli, G | |
dc.contributor.author | Obenauf, AC | |
dc.contributor.author | Oricchio, E | |
dc.contributor.author | Scaffidi, P | |
dc.contributor.author | Sottoriva, A | |
dc.contributor.author | Swarbrick, A | |
dc.contributor.author | Tonon, G | |
dc.contributor.author | Vanharanta, S | |
dc.contributor.author | Zuber, J | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-03-01T11:27:00Z | |
dc.date.available | 2024-03-01T11:27:00Z | |
dc.date.issued | 2024-01-12 | |
dc.identifier | 731491 | |
dc.identifier.citation | Cancer Discovery, 2024, 14 (1), pp. 36 - 48 | en_US |
dc.identifier.issn | 2159-8274 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6169 | |
dc.identifier.eissn | 2159-8290 | |
dc.identifier.eissn | 2159-8290 | |
dc.identifier.doi | 10.1158/2159-8290.CD-23-0530 | |
dc.identifier.doi | 10.1158/2159-8290.CD-23-0530 | |
dc.description.abstract | UNLABELLED: Cancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable genetic changes has provided insights into the mechanisms supporting cancer evolution. However, cancer hallmarks also emerge via heritable nongenetic mechanisms, including epigenetic and chromatin topological changes, and interactions between tumor cells and the tumor microenvironment. Recent findings on tumor evolutionary mechanisms draw a multifaceted picture where heterogeneous forces interact and influence each other while shaping tumor progression. A comprehensive characterization of the cancer evolutionary toolkit is required to improve personalized medicine and biomarker discovery. SIGNIFICANCE: Tumor evolution is fueled by multiple enabling mechanisms. Importantly, genetic instability, epigenetic reprogramming, and interactions with the tumor microenvironment are neither alternative nor independent evolutionary mechanisms. As demonstrated by findings highlighted in this perspective, experimental and theoretical approaches must account for multiple evolutionary mechanisms and their interactions to ultimately understand, predict, and steer tumor evolution. | |
dc.format | Print | |
dc.format.extent | 36 - 48 | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | American Association for Cancer Research (AACR) | en_US |
dc.relation.ispartof | Cancer Discovery | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Epigenomics | |
dc.subject | Precision Medicine | |
dc.subject | Tumor Microenvironment | |
dc.title | Cancer Evolution: A Multifaceted Affair. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-10-23 | |
dc.date.updated | 2024-03-01T11:26:34Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1158/2159-8290.CD-23-0530 | en_US |
rioxxterms.licenseref.startdate | 2024-01-12 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38047596 | |
pubs.issue | 1 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research/Breast Epigenetic Plasticity and Evolution | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1158/2159-8290.cd-23-0530 | |
pubs.volume | 14 | |
icr.researchteam | Breast Epige Plast & Evol | en_US |
icr.researchteam | Evol Genomics & Modelling | en_US |
dc.contributor.icrauthor | Magnani, Luca | |
dc.contributor.icrauthor | Sottoriva, Andrea | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Andrew McKean) on 2024-03-01. Deposit type is initial. No. of files: 1. Files: Cancer Evolution A Multifaceted Affair.pdf | |