dc.contributor.author | van Ewijk, R | |
dc.contributor.author | Chatziantoniou, C | |
dc.contributor.author | Adams, M | |
dc.contributor.author | Bertolini, P | |
dc.contributor.author | Bisogno, G | |
dc.contributor.author | Bouhamama, A | |
dc.contributor.author | Caro-Dominguez, P | |
dc.contributor.author | Charon, V | |
dc.contributor.author | Coma, A | |
dc.contributor.author | Dandis, R | |
dc.contributor.author | Devalck, C | |
dc.contributor.author | De Donno, G | |
dc.contributor.author | Ferrari, A | |
dc.contributor.author | Fiocco, M | |
dc.contributor.author | Gallego, S | |
dc.contributor.author | Giraudo, C | |
dc.contributor.author | Glosli, H | |
dc.contributor.author | Ter Horst, SAJ | |
dc.contributor.author | Jenney, M | |
dc.contributor.author | Klein, WM | |
dc.contributor.author | Leemans, A | |
dc.contributor.author | Leseur, J | |
dc.contributor.author | Mandeville, HC | |
dc.contributor.author | McHugh, K | |
dc.contributor.author | Merks, JHM | |
dc.contributor.author | Minard-Colin, V | |
dc.contributor.author | Moalla, S | |
dc.contributor.author | Morosi, C | |
dc.contributor.author | Orbach, D | |
dc.contributor.author | Ording Muller, L-S | |
dc.contributor.author | Pace, E | |
dc.contributor.author | Di Paolo, PL | |
dc.contributor.author | Perruccio, K | |
dc.contributor.author | Quaglietta, L | |
dc.contributor.author | Renard, M | |
dc.contributor.author | van Rijn, RR | |
dc.contributor.author | Ruggiero, A | |
dc.contributor.author | Sirvent, SI | |
dc.contributor.author | De Luca, A | |
dc.contributor.author | Schoot, RA | |
dc.coverage.spatial | Germany | |
dc.date.accessioned | 2024-04-30T15:53:38Z | |
dc.date.available | 2024-04-30T15:53:38Z | |
dc.date.issued | 2023-11-01 | |
dc.identifier | 10.1007/s00247-023-05745-z | |
dc.identifier.citation | Pediatric Radiology, 2023, 53 (12), pp. 2539 - 2551 | |
dc.identifier.issn | 0301-0449 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6211 | |
dc.identifier.eissn | 1432-1998 | |
dc.identifier.eissn | 1432-1998 | |
dc.identifier.doi | 10.1007/s00247-023-05745-z | |
dc.identifier.doi | 10.1007/s00247-023-05745-z | |
dc.description.abstract | OBJECTIVE: To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma. MATERIAL AND METHODS: We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was performed according to institutional protocols. We performed two-dimensional single-slice tumor delineation. Areas of necrosis or hemorrhage were delineated to be excluded in the primary analysis. Mean, median and 5th and 95th apparent diffusion coefficient (ADC) were extracted. RESULTS: Of 134 included patients, 82 had measurable tumor at diagnosis and response and DW-MRI scans of adequate quality and were included in the analysis. Technical heterogeneity in scan acquisition protocols and scanners was observed. Mean ADC at diagnosis was 1.1 (95% confidence interval [CI]: 1.1-1.2) (all ADC expressed in * 10-3 mm2/s), versus 1.6 (1.5-1.6) at response assessment. The 5th percentile ADC was 0.8 (0.7-0.9) at diagnosis and 1.1 (1.0-1.2) at response. Absolute change in mean ADC after neoadjuvant chemotherapy was 0.4 (0.3-0.5). Exploratory analyses for association between ADC and clinical parameters showed a significant difference in mean ADC at diagnosis for alveolar versus embryonal histology. Landmark analysis at nine weeks after the date of diagnosis showed no significant association (hazard ratio 1.3 [0.6-3.2]) between the mean ADC change and event-free survival. CONCLUSION: A significant change in the 5th percentile and the mean ADC after chemotherapy was observed. Strong heterogeneity was identified in DW-MRI acquisition protocols between centers and in individual patients. | |
dc.format | Print-Electronic | |
dc.format.extent | 2539 - 2551 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | Pediatric Radiology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Biomarker | |
dc.subject | Diffusion magnetic resonance imaging | |
dc.subject | Rhabdomyosarcoma | |
dc.subject | Sarcoma | |
dc.subject | Surrogate marker | |
dc.subject | Adolescent | |
dc.subject | Young Adult | |
dc.subject | Humans | |
dc.subject | Child | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Retrospective Studies | |
dc.subject | Sarcoma | |
dc.subject | Rhabdomyosarcoma | |
dc.title | Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-08-07 | |
dc.date.updated | 2024-04-16T14:46:00Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1007/s00247-023-05745-z | |
rioxxterms.licenseref.startdate | 2023-11-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37682330 | |
pubs.issue | 12 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1007/s00247-023-05745-z | |
pubs.volume | 53 | |
icr.researchteam | Paed & Adolesc Radiother | |
dc.contributor.icrauthor | Mandeville, Henry | |
icr.provenance | Deposited by Henry Mandeville on 2024-04-16. Deposit type is initial. No. of files: 1. Files: Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma an international retrospective study on behalf o.pdf | |