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dc.contributor.authorMerrem, Aen_US
dc.contributor.authorBartzsch, Sen_US
dc.contributor.authorLaissue, Jen_US
dc.contributor.authorOelfke, Uen_US
dc.date.accessioned2017-05-17T15:49:01Z
dc.date.issued2017-05en_US
dc.identifier.citationPhysics in medicine and biology, 2017, 62 (10), pp. 3902 - 3922en_US
dc.identifier.issn0031-9155en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/640
dc.identifier.eissn1361-6560en_US
dc.identifier.doi10.1088/1361-6560/aa68d5en_US
dc.description.abstractMicrobeam Radiation Therapy is an innovative pre-clinical strategy which uses arrays of parallel, tens of micrometres wide kilo-voltage photon beams to treat tumours. These x-ray beams are typically generated on a synchrotron source. It was shown that these beam geometries allow exceptional normal tissue sparing from radiation damage while still being effective in tumour ablation. A final biological explanation for this enhanced therapeutic ratio has still not been found, some experimental data support an important role of the vasculature. In this work, the effect of microbeams on a normal microvascular network of the cerebral cortex was assessed in computer simulations and compared to the effect of homogeneous, seamless exposures at equal energy absorption. The anatomy of a cerebral microvascular network and the inflicted radiation damage were simulated to closely mimic experimental data using a novel probabilistic model of radiation damage to blood vessels. It was found that the spatial dose fractionation by microbeam arrays significantly decreased the vascular damage. The higher the peak-to-valley dose ratio, the more pronounced the sparing effect. Simulations of the radiation damage as a function of morphological parameters of the vascular network demonstrated that the distribution of blood vessel radii is a key parameter determining both the overall radiation damage of the vasculature and the dose-dependent differential effect of microbeam irradiation.en_US
dc.formatPrint-Electronicen_US
dc.format.extent3902 - 3922en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCerebral Cortexen_US
dc.subjectHumansen_US
dc.subjectRadiation Dosageen_US
dc.subjectSynchrotronsen_US
dc.subjectX-Raysen_US
dc.subjectComputer Simulationen_US
dc.subjectMicrovesselsen_US
dc.titleComputational modelling of the cerebral cortical microvasculature: effect of x-ray microbeams versus broad beam irradiation.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1088/1361-6560/aa68d5en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2017-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPhysics in medicine and biologyen_US
pubs.issue10en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublisheden_US
pubs.volume62en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorOelfke, Uween_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/