Browsing Molecular Pathology by author "Ashworth, Alan"
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Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK alpha 2 but not AMPK alpha 1
Ashworth, A (2006-05)Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK alpha 2 but not AMPK alpha 1 Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase ( AMPK), which plays a ... -
Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
Ashworth, A (PUBLIC LIBRARY SCIENCE, 2009-01)The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes. We have determined the impact of Lkb1 deficiency on intestinal homeostasis, particularly focussing on secretory cell ... -
LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.
Woods, A; Heslegrave, AJ; Muckett, PJ; Levene, AP; Clements, M; et al. (2011-02)LKB1 is a 'master' protein kinase implicated in the regulation of metabolism, cell proliferation, cell polarity and tumorigenesis. However, the long-term role of LKB1 in hepatic function is unknown. In the present study, ...