dc.contributor.author | Lin, S | |
dc.contributor.author | Shah, A | |
dc.contributor.author | Hernández-Gil, J | |
dc.contributor.author | Stanziola, A | |
dc.contributor.author | Harriss, BI | |
dc.contributor.author | Matsunaga, TO | |
dc.contributor.author | Long, N | |
dc.contributor.author | Bamber, J | |
dc.contributor.author | Tang, M-X | |
dc.date.accessioned | 2017-07-19T15:02:54Z | |
dc.date.issued | 2017-06-01 | |
dc.identifier.citation | Photoacoustics, 2017, 6 pp. 26 - 36 | |
dc.identifier.issn | 2213-5979 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/718 | |
dc.identifier.eissn | 2213-5979 | |
dc.identifier.doi | 10.1016/j.pacs.2017.04.001 | |
dc.description.abstract | We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 26 - 36 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER GMBH | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-04-08 | |
rioxxterms.versionofrecord | 10.1016/j.pacs.2017.04.001 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Photoacoustics | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Ultrasound & Optical Imaging | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Ultrasound & Optical Imaging | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Ultrasound & Optical Imaging | |
dc.contributor.icrauthor | Shah, Anant | |
dc.contributor.icrauthor | Bamber, Jeffrey | |