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dc.contributor.authorPerez-Lopez, Ren_US
dc.contributor.authorMateo, Jen_US
dc.contributor.authorMossop, Hen_US
dc.contributor.authorBlackledge, MDen_US
dc.contributor.authorCollins, DJen_US
dc.contributor.authorRata, Men_US
dc.contributor.authorMorgan, VAen_US
dc.contributor.authorMacdonald, Aen_US
dc.contributor.authorSandhu, Sen_US
dc.contributor.authorLorente, Den_US
dc.contributor.authorRescigno, Pen_US
dc.contributor.authorZafeiriou, Zen_US
dc.contributor.authorBianchini, Den_US
dc.contributor.authorPorta, Nen_US
dc.contributor.authorHall, Een_US
dc.contributor.authorLeach, MOen_US
dc.contributor.authorde Bono, JSen_US
dc.contributor.authorKoh, D-Men_US
dc.contributor.authorTunariu, Nen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2016-08-23T10:37:36Z
dc.date.issued2017-04en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27875103en_US
dc.identifier.citationRadiology, 2017, 283 (1), pp. 168 - 177en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/71
dc.identifier.eissn1527-1315en_US
dc.identifier.doi10.1148/radiol.2016160646en_US
dc.description.abstractPurpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods A phase II prospective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCRPC included a prospective magnetic resonance (MR) imaging substudy; the study was approved by the institutional research board, and written informed consent was obtained. Whole-body DWI was performed at baseline and after 12 weeks of olaparib administration by using 1.5-T MR imaging. Areas of abnormal signal intensity on DWI images in keeping with bone metastases were delineated to derive total diffusion volume (tDV); five target lesions were also evaluated. Associations of changes in volume of bone metastases and median apparent diffusion coefficient (ADC) with response to treatment were assessed by using the Mann-Whitney test and logistic regression; correlation with prostate-specific antigen level and circulating tumor cell count were assessed by using Spearman correlation (r). Results Twenty-one patients were included. All six responders to olaparib showed a decrease in tDV, while no decrease was observed in all nonresponders; this difference between responders and nonresponders was significant (P = .001). Increases in median ADC were associated with increased odds of response (odds ratio, 1.08; 95% confidence interval [CI]: 1.00, 1.15; P = .04). A positive association was detected between changes in tDV and best percentage change in prostate-specific antigen level and circulating tumor cell count (r = 0.63 [95% CI: 0.27, 0.83] and r = 0.77 [95% CI: 0.51, 0.90], respectively). When assessing five target lesions, decreases in volume were associated with response (odds ratio for volume increase, 0.89; 95% CI: 0.80, 0.99; P = .037). Conclusion This pilot study showed that decreases in volume and increases in median ADC of bone metastases assessed with whole-body DWI can potentially be used as indicators of response to olaparib in mCRPC. Online supplemental material is available for this article.en_US
dc.format.extent168 - 177en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectBone Neoplasmsen_US
dc.subjectDiffusion Magnetic Resonance Imagingen_US
dc.subjectHumansen_US
dc.subjectImage Processing, Computer-Assisteden_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPhthalazinesen_US
dc.subjectPilot Projectsen_US
dc.subjectPiperazinesen_US
dc.subjectProspective Studiesen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectTreatment Outcomeen_US
dc.subjectWhole Body Imagingen_US
dc.titleDiffusion-weighted Imaging as a Treatment Response Biomarker for Evaluating Bone Metastases in Prostate Cancer: A Pilot Study.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-08-01en_US
rioxxterms.versionofrecord10.1148/radiol.2016160646en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2017-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRadiologyen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume283en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamClinical Trials & Statistics Uniten_US
icr.researchteamICR-CTSU Urology and Head and Neck Trials Teamen_US
icr.researchteamProstate Cancer Targeted Therapy Groupen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorLeach, Martinen_US
dc.contributor.icrauthorHall, Emmaen_US
dc.contributor.icrauthorDe Bono, Johannen_US
dc.contributor.icrauthorRata, Mihaelaen_US
dc.contributor.icrauthorKoh, Dow-Muen_US
dc.contributor.icrauthorBlackledge, Matthewen_US
dc.contributor.icrauthorMossop, Helenen_US
dc.contributor.icrauthorPorta, Nuriaen_US
dc.contributor.icrauthorMateo Valderrama, Joaquinen_US
dc.contributor.icrauthorRescigno, Pasqualeen_US
dc.contributor.icrauthorTunariu, Ninaen_US
dc.contributor.icrauthorMarsden,en_US


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