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dc.contributor.authorBlagg, Jen_US
dc.contributor.authorWorkman, Pen_US
dc.date.accessioned2017-07-19T15:35:43Z
dc.date.issued2017-07en_US
dc.identifier.citationCancer cell, 2017, 32 (1), pp. 9 - 25en_US
dc.identifier.issn1535-6108en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/725
dc.identifier.eissn1878-3686en_US
dc.identifier.doi10.1016/j.ccell.2017.06.005en_US
dc.description.abstractSmall-molecule chemical probes or tools have become progressively more important in recent years as valuable reagents to investigate fundamental biological mechanisms and processes causing disease, including cancer. Chemical probes have also achieved greater prominence alongside complementary biological reagents for target validation in drug discovery. However, there is evidence of widespread continuing misuse and promulgation of poor-quality and insufficiently selective chemical probes, perpetuating a worrisome and misleading pollution of the scientific literature. We discuss current challenges with the selection and use of chemical probes, and suggest how biologists can and should be more discriminating in the probes they employ.en_US
dc.formatPrinten_US
dc.format.extent9 - 25en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectMolecular Probesen_US
dc.subjectResearch Designen_US
dc.titleChoose and Use Your Chemical Probe Wisely to Explore Cancer Biology.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-06-09en_US
rioxxterms.versionofrecord10.1016/j.ccell.2017.06.005en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2017-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer cellen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1
pubs.publication-statusPublisheden_US
pubs.volume32en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamMedicinal Chemistry 1en_US
dc.contributor.icrauthorWorkman, Paulen_US
dc.contributor.icrauthorBlagg, Julianen_US


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