Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.
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Date
2017-07-10ICR Author
Author
Blagg, J
Workman, P
Type
Journal Article
Metadata
Show full item recordAbstract
Small-molecule chemical probes or tools have become progressively more important in recent years as valuable reagents to investigate fundamental biological mechanisms and processes causing disease, including cancer. Chemical probes have also achieved greater prominence alongside complementary biological reagents for target validation in drug discovery. However, there is evidence of widespread continuing misuse and promulgation of poor-quality and insufficiently selective chemical probes, perpetuating a worrisome and misleading pollution of the scientific literature. We discuss current challenges with the selection and use of chemical probes, and suggest how biologists can and should be more discriminating in the probes they employ.
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Subject
Humans
Neoplasms
Molecular Probes
Research Design
Research team
Medicinal Chemistry 1
Language
eng
Date accepted
2017-06-09
License start date
2017-07
Citation
Cancer cell, 2017, 32 (1), pp. 9 - 25
Publisher
CELL PRESS