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dc.contributor.authorBrüningk, SCen_US
dc.contributor.authorIjaz, Jen_US
dc.contributor.authorRivens, Ien_US
dc.contributor.authorNill, Sen_US
dc.contributor.authorTer Haar, Gen_US
dc.contributor.authorOelfke, Uen_US
dc.date.accessioned2017-07-21T11:12:06Z
dc.date.issued2018-06en_US
dc.identifier.citationInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2018, 34 (4), pp. 392 - 402en_US
dc.identifier.issn0265-6736en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/740
dc.identifier.eissn1464-5157en_US
dc.identifier.doi10.1080/02656736.2017.1341059en_US
dc.description.abstractCombined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality therapy. The model is motivated by the observation that heat induced radio-sensitisation may be explained by a reduction in the DNA damage repair capacity of heated cells. We assume that this repair is only possible up to a threshold level above which survival will decrease exponentially with dose. Experimental cell survival data from two cell lines (HCT116, Cal27) were considered along with that taken from the literature (baby hamster kidney [BHK] and Chinese hamster ovary cells [CHO]) for HT and combined RT-HT. The AlphaR model was used to study the dependence of clonogenic survival on treatment temperature, and thermal dose R2 ≥ 0.95 for all fits). For HT survival curves (0-80 CEM43 at 43.5-57 °C), the number of free fit AlphaR model parameters could be reduced to two. Both parameters increased exponentially with temperature. We derived the relative biological effectiveness (RBE) or HT treatments at different temperatures, to provide an alternative description of thermal dose, based on our AlphaR model. For combined RT-HT, our analysis is restricted to the linear quadratic arm of the model. We show that, for the range used (20-80 CEM43, 0-12 Gy), thermal dose is a valid indicator of heat induced radio-sensitisation, and that the model parameters can be described as a function thereof. Overall, the proposed model provides a flexible framework for describing cell survival curves, and may contribute to better quantification of heat induced radio-sensitisation, and thermal dose in general.en_US
dc.formatPrint-Electronicen_US
dc.format.extent392 - 402en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCell Lineen_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectDNA Damageen_US
dc.subjectCombined Modality Therapyen_US
dc.subjectHyperthermia, Induceden_US
dc.subjectRadiotherapyen_US
dc.subjectDNA Repairen_US
dc.subjectModels, Theoreticalen_US
dc.subjectCricetinaeen_US
dc.subjectHot Temperatureen_US
dc.titleA comprehensive model for heat-induced radio-sensitisation.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-06-06en_US
rioxxterms.versionofrecord10.1080/02656736.2017.1341059en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-06en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Groupen_US
pubs.issue4en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume34en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamRadiotherapy Physics Modellingen_US
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorNill, Simeonen_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorRivens, Ianen_US
dc.contributor.icrauthorOelfke, Uween_US
dc.contributor.icrauthorBrueningk, Sarahen_US
dc.contributor.icrauthorMarsden,en_US
dc.contributor.icrauthorTer Haar, Gailen_US


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