Application of Liquid Biopsies in Cancer Targeted Therapy.
de Bono, JS
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As a growing body of evidence demonstrates intertumoral and intratumoral heterogeneity and clonal evolution, both during carcinogenesis and also throughout treatment resulting in acquired drug resistance, the utility of blood-based assays or "liquid biopsies" is becoming increasingly recognized in clinical practice and trial design. "Liquid biopsies" provide a less invasive approach to the current gold standard of interrogating tumors by tissue biopsies, which are frequently unfeasible, associated with morbidity, and cannot be performed as often.
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Neoplastic Cells, Circulating
Prostate Cancer Targeted Therapy Group
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Clinical pharmacology and therapeutics, 2017, 102 (5), pp. 745 - 747