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dc.contributor.authorSchmitt, D
dc.contributor.authorNill, S
dc.contributor.authorRoeder, F
dc.contributor.authorGompelmann, D
dc.contributor.authorHerth, F
dc.contributor.authorOelfke, U
dc.date.accessioned2017-08-16T08:52:12Z
dc.date.issued2017-10
dc.identifier.citationStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2017, 193 (10), pp. 840 - 847
dc.identifier.issn0179-7158
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/781
dc.identifier.eissn1439-099X
dc.identifier.doi10.1007/s00066-017-1183-0
dc.description.abstractPurpose Anchored electromagnetic transponders for tumor motion monitoring during lung radiotherapy were clinically evaluated. First, intrafractional motion patterns were analyzed as well as their interfractional variations. Second, intra- and interfractional changes of the geometric transponder positions were investigated.Materials and methods Intrafractional motion data from 7 patients with an upper or middle lobe tumor and three implanted transponders each was used to calculate breathing amplitudes, overall motion amount and motion midlines in three mutual perpendicular directions and three-dimensionally (3D) for 162 fractions. For 6 patients intra- and interfractional variations in transponder distances and in the size of the triangle defined by the transponder locations over the treatment course were determined.Results Mean 3D values of all fractions were up to 4.0, 4.6 and 3.4 mm per patient for amplitude, overall motion amount and midline deviation, respectively. Intrafractional transponder distances varied with standard deviations up to 3.2 mm, while a maximal triangle shrinkage of 36.5% over 39 days was observed.Conclusions Electromagnetic real-time motion monitoring was feasible for all patients. Detected respiratory motion was on average modest in this small cohort without lower lobe tumors, but changes in motion midline were of the same size as the amplitudes and greater midline motion can be observed in some fractions. Intra- and interfractional variations of the geometric transponder positions can be large, so for reliable motion management correlation between transponder and tumor motion needs to be evaluated per patient.
dc.formatPrint-Electronic
dc.format.extent840 - 847
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMonitoring, Ambulatory
dc.subjectRadiotherapy, Conformal
dc.subjectSensitivity and Specificity
dc.subjectReproducibility of Results
dc.subjectEquipment Design
dc.subjectEquipment Failure Analysis
dc.subjectTransducers
dc.subjectRespiratory Mechanics
dc.subjectMotion
dc.subjectPatient Positioning
dc.subjectMagnetometry
dc.titleMotion monitoring during a course of lung radiotherapy with anchored electromagnetic transponders : Quantification of inter- and intrafraction motion and variability of relative transponder positions.
dc.typeJournal Article
dcterms.dateAccepted2017-06-30
rioxxterms.versionofrecord10.1007/s00066-017-1183-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
pubs.issue10
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished
pubs.volume193
pubs.embargo.termsNo embargo
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorOelfke, Uween
dc.contributor.icrauthorNill, Simeonen


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