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dc.contributor.authorSchmitt, Den_US
dc.contributor.authorNill, Sen_US
dc.contributor.authorRoeder, Fen_US
dc.contributor.authorGompelmann, Den_US
dc.contributor.authorHerth, Fen_US
dc.contributor.authorOelfke, Uen_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2017-08-16T08:52:12Z
dc.date.issued2017-10en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28733724en_US
dc.identifier10.1007/s00066-017-1183-0en_US
dc.identifier.citationStrahlenther Onkol, 2017, 193 (10), pp. 840 - 847en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/781
dc.identifier.eissn1439-099Xen_US
dc.identifier.doi10.1007/s00066-017-1183-0en_US
dc.description.abstractPURPOSE: Anchored electromagnetic transponders for tumor motion monitoring during lung radiotherapy were clinically evaluated. First, intrafractional motion patterns were analyzed as well as their interfractional variations. Second, intra- and interfractional changes of the geometric transponder positions were investigated. MATERIALS AND METHODS: Intrafractional motion data from 7 patients with an upper or middle lobe tumor and three implanted transponders each was used to calculate breathing amplitudes, overall motion amount and motion midlines in three mutual perpendicular directions and three-dimensionally (3D) for 162 fractions. For 6 patients intra- and interfractional variations in transponder distances and in the size of the triangle defined by the transponder locations over the treatment course were determined. RESULTS: Mean 3D values of all fractions were up to 4.0, 4.6 and 3.4 mm per patient for amplitude, overall motion amount and midline deviation, respectively. Intrafractional transponder distances varied with standard deviations up to 3.2 mm, while a maximal triangle shrinkage of 36.5% over 39 days was observed. CONCLUSIONS: Electromagnetic real-time motion monitoring was feasible for all patients. Detected respiratory motion was on average modest in this small cohort without lower lobe tumors, but changes in motion midline were of the same size as the amplitudes and greater midline motion can be observed in some fractions. Intra- and interfractional variations of the geometric transponder positions can be large, so for reliable motion management correlation between transponder and tumor motion needs to be evaluated per patient.en_US
dc.format.extent840 - 847en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectElectromagnetic trackingen_US
dc.subjectIntrafraction motionen_US
dc.subjectLung radiotherapyen_US
dc.subjectMotion managementen_US
dc.subjectStability of marker positionsen_US
dc.subjectEquipment Designen_US
dc.subjectEquipment Failure Analysisen_US
dc.subjectHumansen_US
dc.subjectLung Neoplasmsen_US
dc.subjectMagnetometryen_US
dc.subjectMonitoring, Ambulatoryen_US
dc.subjectMotionen_US
dc.subjectPatient Positioningen_US
dc.subjectRadiotherapy, Conformalen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectRespiratory Mechanicsen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectTransducersen_US
dc.titleMotion monitoring during a course of lung radiotherapy with anchored electromagnetic transponders : Quantification of inter- and intrafraction motion and variability of relative transponder positions.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-06-30en_US
rioxxterms.versionofrecord10.1007/s00066-017-1183-0en_US
rioxxterms.licenseref.startdate2017-10en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfStrahlenther Onkolen_US
pubs.issue10en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublisheden_US
pubs.volume193en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorOelfke, Uween_US
dc.contributor.icrauthorNill, Simeonen_US


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