Browsing Radiotherapy and Imaging by author "Eeles, Rosalind"
Now showing items 141-148 of 148
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Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.
Schaid, DJ; McDonnell, SK; FitzGerald, LM; DeRycke, L; Fogarty, Z; et al. (ELSEVIER, 2020-08-13)BACKGROUND: Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are associated with the disease. OBJECTIVE: To detect new genetic variants associated with PCa, ... -
UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants.
Hanson, H; Brady, AF; Crawford, G; Eeles, RA; Gibson, S; et al. (BMJ PUBLISHING GROUP, 2020-06-22)Constitutional pathogenic variants in TP53 are associated with Li-Fraumeni syndrome or the more recently described heritable TP53-related cancer syndrome and are associated with increased lifetime risks of a wide spectrum ... -
Updates in Prostate Cancer Research and Screening in Men at Genetically Higher Risk.
Bancroft, EK; Raghallaigh, HN; Page, EC; Eeles, RA (SPRINGERNATURE, 2021-01-01)PURPOSE OF REVIEW: Prostate cancer (PrCa) is the most common cancer in men in the western world and is a major source of morbidity and mortality. Currently, general population PrCa screening is not recommended due to the ... -
Upfront Docetaxel in the Post-STAMPEDE World: Lessons from an Early Evaluation of Non-trial Usage in Hormone-Sensitive Prostate Cancer.
Patrikidou, A; Uccello, M; Tree, A; Parker, C; Attard, G; et al. (ELSEVIER SCIENCE LONDON, 2017-10-01) -
Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk.
MacInnis, RJ; Schmidt, DF; Makalic, E; Severi, G; FitzGerald, LM; et al. (AMER ASSOC CANCER RESEARCH, 2016-12-01)BACKGROUND: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering ... -
Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations.
Shu, CA; Pike, MC; Jotwani, AR; Friebel, TM; Soslow, RA; et al. (AMER MEDICAL ASSOC, 2016-11-01)IMPORTANCE: The link between BRCA mutations and uterine cancer is unclear. Therefore, although risk-reducing salpingo-oophorectomy (RRSO) is standard treatment among women with BRCA mutations (BRCA+ women), the role of ... -
Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Loveday, C; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; et al. (Impact Journals, LLC, 2018-02-27)Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number ... -
What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021.
Turco, F; Armstrong, A; Attard, G; Beer, TM; Beltran, H; et al. (ELSEVIER, 2022-02-17)Patients with advanced prostate cancer (APC) may be at greater risk for severe illness, hospitalisation, or death from coronavirus disease 2019 (COVID-19) due to male gender, older age, potential immunosuppressive treatments, ...