Browsing Radiotherapy and Imaging by author "Kote-Jarai, Zsofia"
Now showing items 1-20 of 86
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A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
Scarbrough, PM; Weber, RP; Iversen, ES; Brhane, Y; Amos, CI; et al. (AMER ASSOC CANCER RESEARCH, 2016-01-01)BACKGROUND: DNA damage is an established mediator of carcinogenesis, although genome-wide association studies (GWAS) have identified few significant loci. This cross-cancer site, pooled analysis was performed to increase ... -
A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.
Huynh-Le, M-P; Fan, CC; Karunamuni, R; Walsh, EI; Turner, EL; et al. (AMER ASSOC CANCER RESEARCH, 2020-09-01)BACKGROUND: A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. ... -
A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.
Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; et al. (IMPACT JOURNALS LLC, 2016-04-19)Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ... -
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2016-06-01)Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ... -
A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.
Bancroft, EK; Page, EC; Brook, MN; Thomas, S; Taylor, N; et al. (ELSEVIER SCIENCE INC, 2021-10-19)BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and ... -
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.
Darst, BF; Hughley, R; Pfennig, A; Hazra, U; Fan, C; et al. (ELSEVIER, 2022-05-01)A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported in Martinican men with early-onset prostate cancer. Given the role of HOXB13 germline variation in prostate ... -
A Review of Prostate Cancer Genome-Wide Association Studies (GWAS).
Benafif, S; Kote-Jarai, Z; Eeles, RA; PRACTICAL Consortium, (AMER ASSOC CANCER RESEARCH, 2018-08-01)Prostate cancer is the most common cancer in men in Europe and the United States. The genetic heritability of prostate cancer is contributed to by both rarely occurring genetic variants with higher penetrance and moderate ... -
A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.
Macinnis, RJ; Antoniou, AC; Eeles, RA; Severi, G; Al Olama, AA; et al. (WILEY, 2011-07-18)Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) that are independently associated with small increments in risk of prostate cancer, opening up the possibility for using such ... -
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
Karunamuni, RA; Huynh-Le, M-P; Fan, CC; Thompson, W; Eeles, RA; et al. (SPRINGERNATURE, 2021-01-08)BACKGROUND: Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46). MATERIALS AND ... -
Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study.
Brunner, C; Davies, NM; Martin, RM; Eeles, R; Easton, D; et al. (WILEY, 2017-01-01)Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ... -
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Wu, L; Yang, Y; Guo, X; Shu, X-O; Cai, Q; et al. (NATURE PUBLISHING GROUP, 2020-08-06)It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence ... -
Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk.
Wu, L; Shu, X; Bao, J; Guo, X; Kote-Jarai, Z; et al. (AMER ASSOC CANCER RESEARCH, 2019-09-15)Several blood protein biomarkers have been associated with prostate cancer risk. However, most studies assessed only a small number of biomarkers and/or included a small sample size. To identify novel protein biomarkers ... -
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.
Camacho, N; Van Loo, P; Edwards, S; Kay, JD; Matthews, L; et al. (PUBLIC LIBRARY SCIENCE, 2017-09-25)A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ... -
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.
Bonilla, C; Lewis, SJ; Rowlands, M-A; Gaunt, TR; Davey Smith, G; et al. (WILEY, 2016-10-01)Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are ... -
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang, YD; Hurson, AN; Zhang, H; Choudhury, PP; Easton, DF; et al. (NATURE PORTFOLIO, 2020-07-03)Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of ... -
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law, PJ; Timofeeva, M; Fernandez-Rozadilla, C; Broderick, P; Studd, J; et al. (NATURE PUBLISHING GROUP, 2019-05-14)Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ... -
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Schumacher, FR; Al Olama, AA; Berndt, SI; Benlloch, S; Ahmed, M; et al. (NATURE PORTFOLIO, 2018-07-01)Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 ... -
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Gusev, A; Shi, H; Kichaev, G; Pomerantz, M; Li, F; et al. (NATURE PUBLISHING GROUP, 2016-04-07)Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ... -
Blood lipids and prostate cancer: a Mendelian randomization analysis.
Bull, CJ; Bonilla, C; Holly, JMP; Perks, CM; Davies, N; et al. (WILEY, 2016-06-01)Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer ... -
Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.
Adams, CD; Richmond, R; Ferreira, DLS; Spiller, W; Tan, V; et al. (AMER ASSOC CANCER RESEARCH, 2019-01-01)BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise ...