Browsing Radiotherapy and Imaging by author "Patel, Radhika"
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An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation.
Patel, R; Barker, HE; Kyula, J; McLaughlin, M; Dillon, MT; Schick, U; Hafsi, H; Thompson, A; Khoo, V; Harrington, K; Zaidi, S (2017-03)<h4>Purpose</h4>Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been ...