Now showing items 1-2 of 2

    • ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment. 

      Dillon, MT; Bergerhoff, KF; Pedersen, M; Whittock, H; Crespo-Rodriguez, E; Patin, EC; Pearson, A; Smith, HG; Paget, JTE; Patel, RR; Foo, S; Bozhanova, G; Ragulan, C; Fontana, E; Desai, K; Wilkins, AC; Sadanandam, A; Melcher, A; McLaughlin, M; Harrington, KJ (2019-06)
      Purpose ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitize to chemotherapy and radiotherapy preclinically. Limited data have been published about the effect of these drugs on the tumor ...
    • Combination therapy with oncolytic viruses and immune checkpoint inhibitors. 

      Chiu, M; Armstrong, EJL; Jennings, V; Foo, S; Crespo-Rodriguez, E; Bozhanova, G; Patin, EC; McLaughlin, M; Mansfield, D; Baker, G; Grove, L; Pedersen, M; Kyula, J; Roulstone, V; Wilkins, A; McDonald, F; Harrington, K; Melcher, A (2020-06)
      Introduction : Immune checkpoint inhibitors (ICI) have dramatically improved the outcome for cancer patients across multiple tumor types. However the response rates to ICI monotherapy remain relatively low, in part due to ...