Browsing Radiotherapy and Imaging by author "Box, Carol"
Now showing items 1-9 of 9
-
3D tumour spheroids for the prediction of the effects of radiation and hyperthermia treatments.
Brüningk, SC; Rivens, I; Box, C; Oelfke, U; Ter Haar, G (NATURE PUBLISHING GROUP, 2020-02-03)For multimodality therapies such as the combination of hyperthermia and radiation, quantification of biological effects is key for dose prescription and response prediction. Tumour spheroids have a microenvironment that ... -
EGFR signaling in invasion, angiogenesis and metastasis
Box, C; Eccles, SA; Peak, J; Rogers, S; Haley, JD; et al. (Humana Press, 2008-09-25)Tumour invasion and metastasis are the hallmarks of advanced stage cancer and are associated with poor patient prognosis. EGFR is overexpressed in a variety of tumour types and this frequently correlates with a more ... -
Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.
Baker, LCJ; Sikka, A; Price, JM; Boult, JKR; Lepicard, EY; et al. (FRONTIERS MEDIA SA, 2018-07-23)Background: Overexpression of EGFR is a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Patients with HNSCC who respond to EGFR-targeted tyrosine kinase inhibitors (TKIs) eventually develop ... -
Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial.
Nimalasena, S; Gothard, L; Anbalagan, S; Allen, S; Sinnett, V; et al. (ELSEVIER SCIENCE INC, 2020-11-15)PURPOSE: Hydrogen peroxide (H2O2) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is potentially exploitable for the treatment ... -
Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.
Panek, R; Welsh, L; Baker, LCJ; Schmidt, MA; Wong, KH; et al. (AMER ASSOC CANCER RESEARCH, 2017-08-01)Purpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and ... -
Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers.
Denis-Bacelar, AM; Cronin, SE; Da Pieve, C; Paul, RL; Eccles, SA; et al. (SPRINGER HEIDELBERG, 2016-11-25)BACKGROUND: Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study ... -
Quantification of Differential Response of Tumour and Normal Cells to Microbeam Radiation in the Absence of FLASH Effects.
Steel, H; Brüningk, SC; Box, C; Oelfke, U; Bartzsch, SH (MDPI, 2021-06-29)Microbeam radiotherapy (MRT) is a preclinical method of delivering spatially-fractionated radiotherapy aiming to improve the therapeutic window between normal tissue complication and tumour control. Previously, MRT was ... -
Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.
Martinho Costa, M; Shah, A; Rivens, I; Box, C; O'Shea, T; et al. (ELSEVIER GMBH, 2019-03-01)Photoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO2). To facilitate assessment of the variability in sO2 and haemoglobin in tumours, for example in response to therapies, the ... -
The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model.
Papaevangelou, E; Almeida, GS; Box, C; deSouza, NM; Chung, Y-L (WILEY, 2018-08-15)Overexpression of fatty acid synthase (FASN), a key regulator of the de novo synthesis of fatty acids, has been demonstrated in a variety of cancers and is associated with poor prognosis and increased multidrug resistance. ...