Browsing Radiotherapy and Imaging by author "Gear, Jonathan"
Now showing items 1-15 of 15
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Abdo-Man: a 3D-printed anthropomorphic phantom for validating quantitative SIRT.
Gear, JI; Cummings, C; Craig, AJ; Divoli, A; Long, CDC; et al. (SPRINGER, 2016-08-05)BACKGROUND: The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The aim ... -
Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy.
Taprogge, J; Carnegie-Peake, L; Murray, I; Gear, JI; Flux, GD (IOP Publishing Ltd, 2021-11-11)Biokinetic models developed for healthy humans are not appropriate to describe biokinetics in thyroid cancer patients following thyroidectomy. The aim of this study was to adjust the population model for iodine proposed ... -
Characterisation of the attenuation properties of 3D-printed tungsten for use in gamma camera collimation.
Gear, JI; Taprogge, J; White, O; Flux, GD (SPRINGER, 2019-01-07)BACKGROUND: The aim of this work was to characterise the attenuation properties of 3D-printed tungsten and to assess the feasibility for its use in gamma camera collimator manufacture. METHOD: 3D-printed tungsten disks ... -
Comparison of 90Y SIRT predicted and delivered absorbed doses using a PSF conversion method.
Craig, AJ; Murray, I; Denis-Bacelar, AM; Rojas, B; Gear, JI; et al. (ELSEVIER SCI LTD, 2021-07-30)PURPOSE: The aims of this study were to develop and apply a method to correct for the differences in partial volume effects of pre-therapy Technetium-99 m (99mTc)-MAA SPECT and post-therapy Yttrium-90 (90Y) bremsstrahlung ... -
Compartmental Model for 223Ra-Dichloride in Patients With Metastatic Bone Disease From Castration-Resistant Prostate Cancer.
Taprogge, J; Murray, I; Gear, J; Chittenden, SJ; Parker, CC; et al. (ELSEVIER SCIENCE INC, 2018-06-04)PURPOSE: 223Ra-Dichloride is used for treatment of patients with metastatic bone disease from castration-resistant prostate cancer. The uptake and mechanism of action of 223Ra-Dichloride is not well understood. The aim of ... -
EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours.
Gear, J; Chiesa, C; Lassmann, M; Gabiña, PM; Tran-Gia, J; et al. (SPRINGEROPEN, 2020-03-06)The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose assessments. ... -
EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations.
Gear, JI; Cox, MG; Gustafsson, J; Gleisner, KS; Murray, I; et al. (SPRINGER, 2018-12-01)A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed ... -
Effects of Respiratory Motion on Y-90 PET Dosimetry for SIRT.
Walker, MD; Gear, JI; Craig, AJ; McGowan, DR (MDPI, 2022-01-14)Respiratory motion degrades the quantification accuracy of PET imaging by blurring the radioactivity distribution. In the case of post-SIRT PET-CT verification imaging, respiratory motion can lead to inaccuracies in ... -
From fixed activities to personalized treatments in radionuclide therapy: lost in translation?
Flux, GD; Sjogreen Gleisner, K; Chiesa, C; Lassmann, M; Chouin, N; et al. (SPRINGER, 2018-01-01) -
InfuShield: a shielded enclosure for administering therapeutic radioisotope treatments using standard syringe pumps.
Rushforth, DP; Pratt, BE; Chittenden, SJ; Murray, IS; Causer, L; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2017-03-01)The administration of radionuclide therapies presents significant radiation protection challenges. The aim of this work was to develop a delivery system for intravenous radioisotope therapies to substantially moderate ... -
Objective comparison of lesion detectability in low and medium-energy collimator iodine-123 mIBG images using a channelized Hotelling observer.
Gregory, RA; Murray, I; Gear, J; Aldridge, MD; Levine, D; et al. (IOP PUBLISHING LTD, 2017-01-07)Iodine-123 mIBG imaging is widely regarded as a gold standard for diagnostic studies of neuroblastoma and adult neuroendocrine cancer although the optimal collimator for tumour imaging remains undetermined. Low-energy (LE) ... -
Quantitative Dual-Isotope Planar Imaging of Thorium-227 and Radium-223 Using Defined Energy Windows.
Murray, I; Rojas, B; Gear, J; Callister, R; Cleton, A; et al. (MARY ANN LIEBERT, INC, 2020-09-01)Introduction: Thorium-227 is an alpha-emitting radioisotope with potential therapeutic applications in targeted alpha therapy. Thorium-227 decays to Radium-223, which may have an independent biodistribution to that of the ... -
Radioactive 3D printing for the production of molecular imaging phantoms.
Gear, JI; Cummings, C; Sullivan, J; Cooper-Rayner, N; Downs, P; et al. (IOP Publishing Ltd, 2020-09-08)Quality control tests of molecular imaging systems are hampered by the complexity of phantom preparation. It is proposed that radioisotopes can be directly incorporated into photo-polymer resins. Use of the radio-polymer ... -
SOLLID - a single centre study to develop methods to investigate the effects of low radiation doses within nuclear medicine, to enable multicentre epidemiological investigations.
Flux, G; Murray, I; Rushforth, D; Gape, P; Abreu, C; et al. (BRITISH INST RADIOLOGY, 2021-03-01)There is continuing debate concerning the risks of secondary malignancies from low levels of radiation exposure. The current model used for radiation protection is predicated on the assumption that even very low levels of ... -
Uncertainty analysis of tumour absorbed dose calculations in molecular radiotherapy.
Finocchiaro, D; Gear, JI; Fioroni, F; Flux, GD; Murray, I; et al. (SPRINGER, 2020-10-12)BACKGROUND: Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored ...