Browsing Radiotherapy and Imaging by author "Somaiah, Navita"
Now showing items 21-35 of 35
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Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers.
Machiels, M; Oulkadi, R; Tramm, T; Stecklein, SR; Somaiah, N; et al. (CHURCHILL LIVINGSTONE, 2023-10-01)Radiation therapy (RT) has long been fundamental for the curative treatment of breast cancer. While substantial progress has been made in the anatomical and technological precision of RT delivery, and some approaches to ... -
Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers.
Cruz-Garcia, L; O'Brien, G; Donovan, E; Gothard, L; Boyle, S; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2018-07-01)For triage purposes following a nuclear accident, blood-based gene expression biomarkers can provide rapid dose estimates for a large number of individuals. Ionizing-radiation-responsive genes are regulated through the DNA ... -
Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial.
Nimalasena, S; Gothard, L; Anbalagan, S; Allen, S; Sinnett, V; et al. (ELSEVIER SCIENCE INC, 2020-11-15)PURPOSE: Hydrogen peroxide (H2O2) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is potentially exploitable for the treatment ... -
Ki67 Is an Independent Predictor of Recurrence in the Largest Randomized Trial of 3 Radiation Fractionation Schedules in Localized Prostate Cancer.
Wilkins, AC; Gusterson, B; Szijgyarto, Z; Haviland, J; Griffin, C; et al. (ELSEVIER SCIENCE INC, 2018-06-01)PURPOSE: To assess whether the cellular proliferation marker Ki67 provides prognostic information and predicts response to radiation therapy fractionation in patients with localized prostate tumors participating in a ... -
Local control and toxicity after hypofractionated accelerated palliative RT in breast cancer
Webb, K; Gothard, L; Mohammed, K; Kirby, A; Locke, I; et al. (ELSEVIER IRELAND LTD, 2022-05-01) -
Locoregional control and toxicity following high-dose hypofractionated and accelerated palliative radiotherapy regimens in breast cancer.
Webb, K; Gothard, L; Mohammed, K; Kirby, AM; Locke, I; et al. (ELSEVIER SCIENCE LONDON, 2023-09-01)AIMS: For patients with locally advanced primary/recurrent breast cancer, radiotherapy is an effective treatment for locoregional control. 36 Gy in 6 Gy once-weekly fractions is a commonly used schedule, but there are no ... -
Outcomes of Different Quality of Life Assessment Modalities After Breast Cancer Therapy: A Network Meta-analysis.
Kastora, SL; Holmquist, A; Valachis, A; Rocco, N; Meattini, I; et al. (AMER MEDICAL ASSOC, 2023-06-01)IMPORTANCE: Improvement in clinical understanding of the priorities of patients with breast cancer (BC) regarding postoperative aesthetic outcomes (AOs) is needed. OBJECTIVE: To assess expert panel and computerized evaluation ... -
Preoperative breast radiation therapy: Indications and perspectives.
Lightowlers, SV; Boersma, LJ; Fourquet, A; Kirova, YM; Offersen, BV; et al. (ELSEVIER SCI LTD, 2017-09-01)Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current ... -
Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility study.
Thiruchelvam, PTR; Leff, DR; Godden, AR; Cleator, S; Wood, SH; et al. (ELSEVIER SCIENCE INC, 2022-04-07)BACKGROUND: Radiotherapy before mastectomy and autologous free-flap breast reconstruction can avoid adverse radiation effects on healthy donor tissues and delays to adjuvant radiotherapy. However, evidence for this treatment ... -
Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy.
Wedlake, L; Shaw, C; McNair, H; Lalji, A; Mohammed, K; et al. (OXFORD UNIV PRESS, 2017-09-01)Background: Therapeutic radiotherapy is an important treatment of pelvic cancers. Historically, low-fiber diets have been recommended despite a lack of evidence and potentially beneficial mechanisms of fiber.Objective: ... -
Science in Focus: Biological Optimisation of Radiotherapy Fraction Size in an Era of Immune Oncology.
Wilkins, A; Melcher, A; Somaiah, N (ELSEVIER SCIENCE LONDON, 2018-10-01) -
Science in Focus; Biological optimisation of radiotherapy fraction
Somaiah, N; Wilkins, A; Melcher, A -
The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group Workshop: Translating Novel Discoveries to and from the Clinic.
Chan Wah Hak, C; Dean, JA; Hill, MA; Somaiah, N; National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group 1(☆), (ELSEVIER SCIENCE LONDON, 2023-12-01) -
TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells.
Anbalagan, S; Ström, C; Downs, JA; Jeggo, PA; McBay, D; et al. (NATURE PORTFOLIO, 2021-03-29)Recent clinical trials in breast and prostate cancer have established that fewer, larger daily doses (fractions) of radiotherapy are safe and effective, but these do not represent personalised dosing on a patient-by-patient ...