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Computational science-enabled radiological pathology for the non-invasive mapping of tumour heterogeneity in childhood neuroblastoma
(Institute of Cancer Research (University Of London), 2021-01-31)
Neuroblastoma is a common childhood solid tumour that accounts for 15% of all cancer paediatric deaths. This thesis addresses key deficiencies in our ability to define, monitor and predict neuroblastoma heterogeneity for ...
Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography.
(AMER ASSOC CANCER RESEARCH, 2019-11-15)
Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and metastasis. Therefore, stromal modulating therapies and accompanying biomarkers are being developed to target ECM stiffness. Magnetic ...
Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography.
(WILEY, 2023-06-01)
Hyaluronan (HA) is a key component of the dense extracellular matrix in breast cancer, and its accumulation is associated with poor prognosis and metastasis. Pegvorhyaluronidase alfa (PEGPH20) enzymatically degrades HA and ...