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Finite Element simulation of methods for improving tissue ultrasound backscatter coefficient estimation
(Institute of Cancer Research (University Of London), 2023-10-02)
This thesis will describe the efforts to generate Finite Element simulations of methods to improve the accuracy and reliability of backscatter coefficient methods (BSC). BSC measurements are a promising diagnostic tool in ...
Drug delivery across the blood-brain barrier using short-pulse focused ultrasound and microbubbles for the treatment of diffuse intrinsic pontine glioma
(Institute of Cancer Research (University Of London), 2023-09-01)
The blood-brain barrier (BBB) prevents unwanted substances from entering the brain, but also blocks entry of therapeutic agents, posing difficulties for treating brain cancers such as diffuse intrinsic pontine glioma (DIPG) ...
Defining novel immune biomarkers of prognosis and immunotherapy sensitivity in gastro-oesophageal and colorectal cancers
(Institute of Cancer Research (University Of London), 2023-11-28)
Background
Gastro-oesophageal adenocarcinomas (GOAs) frequently recur after resection; prognostic and predictive markers are absent. Mismatch repair-deficient (MMRd) GOAs have high mutational burden, are frequently ...