dc.contributor.author | O'Leary, B | |
dc.contributor.author | Finn, RS | |
dc.contributor.author | Turner, NC | |
dc.date.accessioned | 2017-09-08T13:50:27Z | |
dc.date.accessioned | 2017-09-08T13:58:32Z | |
dc.date.issued | 2016-07-01 | |
dc.identifier.citation | Nature reviews. Clinical oncology, 2016, 13 (7), pp. 417 - 430 | |
dc.identifier.issn | 1759-4774 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/819 | |
dc.identifier.eissn | 1759-4782 | |
dc.identifier.doi | 10.1038/nrclinonc.2016.26 | |
dc.description.abstract | Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at the heart of cancer as a pathological process. Clinical implementation of first-generation, nonselective CDK inhibitors, designed to inhibit this proliferation, was originally hampered by the high risk of toxicity and lack of efficacy noted with these agents. The emergence of a new generation of selective CDK4/6 inhibitors, including ribociclib, abemaciclib and palbociclib, has enabled tumour types in which CDK4/6 has a pivotal role in the G1-to-S-phase cell-cycle transition to be targeted with improved effectiveness, and fewer adverse effects. Results of pivotal phase III trials investigating palbociclib in patients with advanced-stage oestrogen receptor (ER)-positive breast cancer have demonstrated a substantial improvement in progression-free survival, with a well-tolerated toxicity profile. Mechanisms of acquired resistance to CDK4/6 inhibitors are beginning to emerge that, although unwelcome, might enable rational post-CDK4/6 inhibitor therapeutic strategies to be identified. Extending the use of CDK4/6 inhibitors beyond ER-positive breast cancer is challenging, and will likely require biomarkers that are predictive of a response, and the use of combination therapies in order to optimize CDK4/6 targeting. | |
dc.format | Print-Electronic | |
dc.format.extent | 417 - 430 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.replaces | https://repository.icr.ac.uk/handle/internal/818 | |
dc.relation.replaces | internal/818 | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Breast Neoplasms | |
dc.subject | Aminopyridines | |
dc.subject | Piperazines | |
dc.subject | Pyridines | |
dc.subject | Benzimidazoles | |
dc.subject | Purines | |
dc.subject | Cyclin D1 | |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject | Cell Cycle | |
dc.subject | Forecasting | |
dc.subject | Female | |
dc.subject | Cyclin-Dependent Kinase 4 | |
dc.subject | Cyclin-Dependent Kinase 6 | |
dc.subject | Clinical Trials as Topic | |
dc.subject | Molecular Targeted Therapy | |
dc.title | Treating cancer with selective CDK4/6 inhibitors. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1038/nrclinonc.2016.26 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature reviews. Clinical oncology | |
pubs.issue | 7 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology | |
pubs.publication-status | Published | |
pubs.volume | 13 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular Oncology | |
dc.contributor.icrauthor | O'Leary, Benjamin | |
dc.contributor.icrauthor | Turner, Nicholas | |