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dc.contributor.authorDenholm, R
dc.contributor.authorDe Stavola, B
dc.contributor.authorHipwell, JH
dc.contributor.authorDoran, SJ
dc.contributor.authorBusana, MC
dc.contributor.authorLeach, MO
dc.contributor.authorHawkes, DJ
dc.contributor.authorDos-Santos-Silva, I
dc.date.accessioned2017-10-24T08:21:35Z
dc.date.issued2018-06
dc.identifier.citationAmerican journal of epidemiology, 2018, 187 (6), pp. 1259 - 1268
dc.identifier.issn0002-9262
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/855
dc.identifier.eissn1476-6256
dc.identifier.doi10.1093/aje/kwx358
dc.description.abstractMammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance imaging (MRI) breast-tissue composition at age 21 years with prospectively collected measurements of body size and composition from birth to early adulthood and markers of puberty (all standardized) in a sample of 500 nulliparous women from a prebirth cohort of children born in Avon, United Kingdom, in 1991-1992 and followed up to 2011-2014. Linear models were fitted to estimate relative change in MRI percent water, which is equivalent to mammographic percent density, associated with a 1-standard-deviation increase in the exposure of interest. In mutually adjusted analyses, MRI percent water was positively associated with birth weight (relative change (RC) = 1.03, 95% confidence interval (CI): 1.00, 1.06) and pubertal height growth (RC = 1.07, 95% CI: 1.02, 1.13) but inversely associated with pubertal weight growth (RC = 0.86, 95% CI: 0.84, 0.89) and changes in dual-energy x-ray absorptiometry percent body fat mass (e.g., for change between ages 11 years and 13.5 years, RC = 0.96, 95% CI: 0.93, 0.99). Ages at thelarche and menarche were positively associated with MRI percent water, but these associations did not persist upon adjustment for height and weight growth. These findings support the hypothesis that growth trajectories influence breast-tissue composition in young women, whereas puberty plays no independent role.
dc.formatPrint
dc.format.extent1259 - 1268
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectBreast
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectProspective Studies
dc.subjectBody Composition
dc.subjectPuberty
dc.subjectSexual Maturation
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectYoung Adult
dc.titleGrowth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.
dc.typeJournal Article
dcterms.dateAccepted2017-11-01
rioxxterms.funderThe Institute of Cancer Research
rioxxterms.identifier.projectUnspecified
rioxxterms.versionofrecord10.1093/aje/kwx358
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAmerican journal of epidemiology
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume187
pubs.embargo.termsNot known
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorDoran, Simonen
dc.contributor.icrauthorLeach, Martinen


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