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dc.contributor.authorFast, MF
dc.contributor.authorKamerling, CP
dc.contributor.authorZiegenhein, P
dc.contributor.authorMenten, MJ
dc.contributor.authorBedford, JL
dc.contributor.authorNill, S
dc.contributor.authorOelfke, U
dc.date.accessioned2017-10-25T10:57:33Z
dc.date.issued2016-02-21
dc.identifier.citationPhysics in medicine and biology, 2016, 61 (4), pp. 1546 - 1562
dc.identifier.issn0031-9155
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/875
dc.identifier.eissn1361-6560
dc.identifier.doi10.1088/0031-9155/61/4/1546
dc.description.abstractBy adapting to the actual patient anatomy during treatment, tracked multi-leaf collimator (MLC) treatment deliveries offer an opportunity for margin reduction and healthy tissue sparing. This is assumed to be especially relevant for hypofractionated protocols in which intrafractional motion does not easily average out. In order to confidently deliver tracked treatments with potentially reduced margins, it is necessary to monitor not only the patient anatomy but also the actually delivered dose during irradiation. In this study, we present a novel real-time online dose reconstruction tool which calculates actually delivered dose based on pre-calculated dose influence data in less than 10 ms at a rate of 25 Hz. Using this tool we investigate the impact of clinical target volume (CTV) to planning target volume (PTV) margins on CTV coverage and organ-at-risk dose. On our research linear accelerator, a set of four different CTV-to-PTV margins were tested for three patient cases subject to four different motion conditions. Based on this data, we can conclude that tracking eliminates dose cold spots which can occur in the CTV during conventional deliveries even for the smallest CTV-to-PTV margin of 1 mm. Changes of organ-at-risk dose do occur frequently during MLC tracking and are not negligible in some cases. Intrafractional dose reconstruction is expected to become an important element in any attempt of re-planning the treatment plan during the delivery based on the observed anatomy of the day.
dc.formatPrint-Electronic
dc.format.extent1546 - 1562
dc.languageeng
dc.language.isoeng
dc.publisherIOP PUBLISHING LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectRadiotherapy, Conformal
dc.subjectRadiotherapy Dosage
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectMotion
dc.subjectMale
dc.titleAssessment of MLC tracking performance during hypofractionated prostate radiotherapy using real-time dose reconstruction.
dc.typeJournal Article
rioxxterms.versionofrecord10.1088/0031-9155/61/4/1546
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPhysics in medicine and biology
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning/Radiotherapy treatment planning (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning/Radiotherapy treatment planning (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume61
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modelling
icr.researchteamRadiotherapy treatment planning
dc.contributor.icrauthorMenten, Martin
dc.contributor.icrauthorNill, Simeon


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