Browsing Structural Biology by author "Pena, Vladimir"

Now showing items 1-5 of 5

    • Alternative catalytic residues in the active site of Esco acetyltransferases. 

      Ajam, T; De, I; Petkau, N; Whelan, G; Pena, V; et al. (NATURE PUBLISHING GROUP, 2020-06-17)
      Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, and SA1/SA2 form a ring-like structure encircling the DNA. Cohesins play a key role in the expression, repair, and segregation of eukaryotic genomes. ...

    • An integrated model for termination of RNA polymerase III transcription. 

      Xie, J; Aiello, U; Clement, Y; Haidara, N; Girbig, M; et al. (American Association for the Advancement of Science (AAAS), 2022-07-15)
      RNA polymerase III (RNAPIII) synthesizes essential and abundant noncoding RNAs such as transfer RNAs. Controlling RNAPIII span of activity by accurate and efficient termination is a challenging necessity to ensure robust ...

    • Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine. 

      Mieczkowski, M; Steinmetzger, C; Bessi, I; Lenz, A-K; Schmiedel, A; et al. (NATURE RESEARCH, 2021-06-10)
      Fluorogenic RNA aptamers are synthetic functional RNAs that specifically bind and activate conditional fluorophores. The Chili RNA aptamer mimics large Stokes shift fluorescent proteins and exhibits high affinity for ...

    • Structural basis of catalytic activation in human splicing. 

      Schmitzová, J; Cretu, C; Dienemann, C; Urlaub, H; Pena, V (NATURE PORTFOLIO, 2023-05-25)
      Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact and the ...

    • Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors 

      Cretu, C; Gee, P; Liu, X; Agrawal, A; Nguyen, T-V; et al. (Springer Science and Business Media LLC, 2021-07-23)
      <jats:title>Abstract</jats:title><jats:p>Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy. ...