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Beyond genomics - Targeting the epigenome in diffuse large B-cell lymphoma.

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Publication Date
2017-09
ICR Author
Cunningham, David
Chau, Ian
Marsden,
Author
Kühnl, A
Cunningham, D
Chau, I
Type
Journal Article
Metadata
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Abstract
After decades of intense research on genetic alterations in cancer and successful implementation of genetically-based targeted therapies, the field of cancer epigenetics is only beginning to be fully recognized. The discovery of frequent mutations in genes modifying the epigenome in diffuse large B-cell lymphoma (DLBCL) has highlighted the outstanding role of epigenetic deregulation in this disease. Identification of epigenetically-driven DLBCL subgroups and development of novel epigenetic drugs have rapidly advanced. However, further insights are needed into the biological consequences of epigenetic alterations and the possibility of restoring the aberrant epigenome with specific therapies to bring this treatment concept further into clinical practice. This review will summarize the main epigenetic changes found in DLBCL and their potential for precision medicine approaches.
URL
https://repository.icr.ac.uk/handle/internal/931
Collections
  • Clinical Studies
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Funder
The Institute of Cancer Research (Grant ID: Unspecified)
Version of record
10.1016/j.ctrv.2017.07.009
Subject
Diffuse large B cell lymphoma
Epigenetic therapies
Epigenome
Epigenesis, Genetic
Female
Forecasting
Genetic Predisposition to Disease
Genetic Therapy
Genomics
Humans
Lymphoma, Large B-Cell, Diffuse
Male
Molecular Targeted Therapy
Precision Medicine
Treatment Outcome
Research team
Medicine (RMH Smith Cunningham)
Language
eng
Date accepted
2017-07-31
License start date
2017-09
Citation
Cancer Treat Rev, 2017, 59 pp. 132 - 137

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