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Drug discovery in advanced prostate cancer: translating biology into therapy.

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Date
2016-10
ICR Author
Al-Lazikani, Bissan
Workman, Paul
De Bono, Johann
Yap, Timothy
Author
Yap, TA
Smith, AD
Ferraldeschi, R
Al-Lazikani, B
Workman, P
de Bono, JS
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Type
Journal Article
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Abstract
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the identification of novel drug targets and potent molecularly targeted therapeutics for this disease. In this article, we review recent advances in prostate cancer target identification for drug discovery and discuss their promise and associated challenges. We review the evolving therapeutic landscape of CRPC and discuss issues associated with precision medicine as well as challenges encountered with immunotherapy for this disease. Finally, we envision the future management of CRPC, highlighting the use of circulating biomarkers and modern clinical trial designs.
URI
https://repository.icr.ac.uk/handle/internal/950
DOI
https://doi.org/10.1038/nrd.2016.120
Collections
  • Cancer Therapeutics
  • Clinical Studies
Subject
Animals
Humans
Antineoplastic Agents
Male
Drug Discovery
Molecular Targeted Therapy
Translational Medical Research
Genetic Therapy
Prostatic Neoplasms, Castration-Resistant
Biomarkers, Tumor
Research team
Computational Biology and Chemogenomics
Medicine Drug Development Unit (de Bono)
Prostate Cancer Targeted Therapy Group
Language
eng
Date accepted
2016-07-22
License start date
2016-10
Citation
Nature reviews. Drug discovery, 2016, 15 (10), pp. 699 - 718

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