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dc.contributor.authorMorfopoulou, Sen_US
dc.contributor.authorMee, ETen_US
dc.contributor.authorConnaughton, SMen_US
dc.contributor.authorBrown, JRen_US
dc.contributor.authorGilmour, Ken_US
dc.contributor.authorChong, WKKen_US
dc.contributor.authorDuprex, WPen_US
dc.contributor.authorFerguson, Den_US
dc.contributor.authorHubank, Men_US
dc.contributor.authorHutchinson, Cen_US
dc.contributor.authorKaliakatsos, Men_US
dc.contributor.authorMcQuaid, Sen_US
dc.contributor.authorPaine, Sen_US
dc.contributor.authorPlagnol, Ven_US
dc.contributor.authorRuis, Cen_US
dc.contributor.authorVirasami, Aen_US
dc.contributor.authorZhan, Hen_US
dc.contributor.authorJacques, TSen_US
dc.contributor.authorSchepelmann, Sen_US
dc.contributor.authorQasim, Wen_US
dc.contributor.authorBreuer, Jen_US
dc.date.accessioned2017-12-19T15:15:19Z
dc.date.issued2017-01en_US
dc.identifier.citationActa neuropathologica, 2017, 133 (1), pp. 139 - 147en_US
dc.identifier.issn0001-6322en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/982
dc.identifier.eissn1432-0533en_US
dc.identifier.doi10.1007/s00401-016-1629-yen_US
dc.description.abstractRoutine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuVJL5) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuVJL5 associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines. The diagnosis was only possible by deep sequencing of the brain biopsy. Sequence comparison of the vaccine batch to the MuVJL5 isolated from brain identified biased hypermutation, particularly in the matrix gene, similar to those found in measles from cases of SSPE. The findings provide unique insights into the pathogenesis of paramyxovirus brain infections.en_US
dc.formatPrint-Electronicen_US
dc.format.extent139 - 147en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBrainen_US
dc.subjectHumansen_US
dc.subjectMumps virusen_US
dc.subjectEncephalitis, Viralen_US
dc.subjectSevere Combined Immunodeficiencyen_US
dc.subjectChronic Diseaseen_US
dc.subjectMumps Vaccineen_US
dc.subjectBiopsyen_US
dc.subjectFatal Outcomeen_US
dc.subjectInfanten_US
dc.subjectMaleen_US
dc.subjectHigh-Throughput Nucleotide Sequencingen_US
dc.titleDeep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-10-04en_US
rioxxterms.versionofrecord10.1007/s00401-016-1629-yen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2017-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfActa neuropathologicaen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics/Translational Genomics (hon.)
pubs.publication-statusPublisheden_US
pubs.volume133en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamTranslational Genomicsen_US
dc.contributor.icrauthorHubank, Michaelen_US


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