dc.contributor.author | Morfopoulou, S | |
dc.contributor.author | Mee, ET | |
dc.contributor.author | Connaughton, SM | |
dc.contributor.author | Brown, JR | |
dc.contributor.author | Gilmour, K | |
dc.contributor.author | Chong, WKK | |
dc.contributor.author | Duprex, WP | |
dc.contributor.author | Ferguson, D | |
dc.contributor.author | Hubank, M | |
dc.contributor.author | Hutchinson, C | |
dc.contributor.author | Kaliakatsos, M | |
dc.contributor.author | McQuaid, S | |
dc.contributor.author | Paine, S | |
dc.contributor.author | Plagnol, V | |
dc.contributor.author | Ruis, C | |
dc.contributor.author | Virasami, A | |
dc.contributor.author | Zhan, H | |
dc.contributor.author | Jacques, TS | |
dc.contributor.author | Schepelmann, S | |
dc.contributor.author | Qasim, W | |
dc.contributor.author | Breuer, J | |
dc.date.accessioned | 2017-12-19T15:15:19Z | |
dc.date.issued | 2017-01 | |
dc.identifier.citation | Acta neuropathologica, 2017, 133 (1), pp. 139 - 147 | |
dc.identifier.issn | 0001-6322 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/982 | |
dc.identifier.eissn | 1432-0533 | |
dc.identifier.doi | 10.1007/s00401-016-1629-y | |
dc.description.abstract | Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV JL5 ) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuV JL5 associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines. The diagnosis was only possible by deep sequencing of the brain biopsy. Sequence comparison of the vaccine batch to the MuV JL5 isolated from brain identified biased hypermutation, particularly in the matrix gene, similar to those found in measles from cases of SSPE. The findings provide unique insights into the pathogenesis of paramyxovirus brain infections. | |
dc.format | Print-Electronic | |
dc.format.extent | 139 - 147 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Brain | |
dc.subject | Humans | |
dc.subject | Mumps virus | |
dc.subject | Encephalitis, Viral | |
dc.subject | Severe Combined Immunodeficiency | |
dc.subject | Chronic Disease | |
dc.subject | Mumps Vaccine | |
dc.subject | Biopsy | |
dc.subject | Fatal Outcome | |
dc.subject | Infant | |
dc.subject | Male | |
dc.subject | High-Throughput Nucleotide Sequencing | |
dc.title | Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-10-04 | |
rioxxterms.versionofrecord | 10.1007/s00401-016-1629-y | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Acta neuropathologica | |
pubs.issue | 1 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics/Translational Genomics (hon.) | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics/Translational Genomics (hon.) | |
pubs.publication-status | Published | |
pubs.volume | 133 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Translational Genomics | en_US |
dc.contributor.icrauthor | Hubank, Michael | en |