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dc.contributor.authorHarding, Den_US
dc.contributor.authorGiles, SLen_US
dc.contributor.authorBrown, MRDen_US
dc.contributor.authorTer Haar, GRen_US
dc.contributor.authorvan den Bosch, Men_US
dc.contributor.authorBartels, LWen_US
dc.contributor.authorKim, Y-Sen_US
dc.contributor.authorDeppe, Men_US
dc.contributor.authordeSouza, NMen_US
dc.date.accessioned2018-01-11T14:27:27Z
dc.date.issued2018-04en_US
dc.identifier.citationClinical oncology (Royal College of Radiologists (Great Britain)), 2018, 30 (4), pp. 233 - 242en_US
dc.identifier.issn0936-6555en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/992
dc.identifier.eissn1433-2981en_US
dc.identifier.doi10.1016/j.clon.2017.12.023en_US
dc.description.abstractAIMS:To determine quality of life (QoL) outcomes after palliation of pain from bone metastases using magnetic resonance-guided high intensity focused ultrasound (MR-guided HIFU), measured using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C15-PAL and the QLQ-BM22 questionnaires. MATERIALS AND METHODS:Twenty patients undergoing MR-guided HIFU in an international multicentre trial self-completed the QLQ-C15-PAL and QLQ-BM22 questionnaires before and on days 7, 14, 30, 60 and 90 post-treatment. Descriptive statistics were used to represent changes in symptom and functional scales over time and to determine their clinical significance. QoL changes were compared in pain responders and non-responders (who were classified according to change in worst pain score and analgesic intake, between baseline and day 30). RESULTS:Eighteen patients had analysable QoL data. Clinically significant improvements were seen in the QoL scales of physical functioning, fatigue, appetite loss, nausea and vomiting, constipation and pain in the 53% of patients who were classified as responders at day 30. No significant changes were seen in the 47% of patients who were non-responders at this time point. CONCLUSION:Local treatment of pain from bone metastases with MR-guided HIFU, even in the presence of disseminated malignancy, has a substantial positive effect on physical functioning, and improves other symptomatic QoL measures. This indicated a greater response to treatment over and above pain control alone. MR-guided HIFU is non-invasive and should be considered for patients with localised metastatic bone pain and poor QoL.en_US
dc.formatPrint-Electronicen_US
dc.format.extent233 - 242en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectBone Neoplasmsen_US
dc.subjectPalliative Careen_US
dc.subjectUltrasonic Therapyen_US
dc.subjectQuality of Lifeen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectSurveys and Questionnairesen_US
dc.subjectCancer Painen_US
dc.titleEvaluation of Quality of Life Outcomes Following Palliative Treatment of Bone Metastases with Magnetic Resonance-guided High Intensity Focused Ultrasound: An International Multicentre Study.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-11-29en_US
rioxxterms.versionofrecord10.1016/j.clon.2017.12.023en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfClinical oncology (Royal College of Radiologists (Great Britain))en_US
pubs.issue4en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublisheden_US
pubs.volume30en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamMagnetic Resonanceen_US
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorGiles, Sharonen_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthordeSouza, Nanditaen_US
dc.contributor.icrauthorTer Haar, Gailen_US


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