Now showing items 1-4 of 4

    • ELM: the status of the 2010 eukaryotic linear motif resource. 

      Gould, CM; Diella, F; Via, A; Puntervoll, P; Gemünd, C; Chabanis-Davidson, S; Michael, S; Sayadi, A; Bryne, JC; Chica, C; Seiler, M; Davey, NE; Haslam, N; Weatheritt, RJ; Budd, A; Hughes, T; Pas, J; Rychlewski, L; Travé, G; Aasland, R; Helmer-Citterich, M; Linding, R; Gibson, TJ (2010-01)
      Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. ...
    • The functional importance of structure in unstructured protein regions. 

      Davey, NE (2019-06)
      After two decades of research, intrinsically disordered regions (IDRs) are established as a widespread phenomenon. The growing understanding of the significant functional role of IDRs has challenged the structure-function ...
    • The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C. 

      Di Fiore, B; Wurzenberger, C; Davey, NE; Pines, J (2016-12-15)
      The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ...
    • SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. 

      Sebaa, R; Johnson, J; Pileggi, C; Norgren, M; Xuan, J; Sai, Y; Tong, Q; Krystkowiak, I; Bondy-Chorney, E; Davey, NE; Krogan, N; Downey, M; Harper, M-E (2019-07)
      OBJECTIVE: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control ...