The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome.
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Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.
Short linear motifs (SLiMs)
Amino Acid Motifs
Short Linear Motif
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Current Opinion in Structural Biology, 2023, 80 pp. 102593 -
CURRENT BIOLOGY LTD