The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome.
Date
2023-06-01ICR Author
Author
Davey, NE
Simonetti, L
Ivarsson, Y
Type
Journal Article
Metadata
Show full item recordAbstract
Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.
Collections
Subject
High-throughput methods
Interactomics
Protein–peptide interactions
Protein–protein interactions
Short linear motifs (SLiMs)
Humans
Proteome
Amino Acid Motifs
Research team
Short Linear Motif
Language
eng
Date accepted
2023-03-17
License start date
2023-06-01
Citation
Current Opinion in Structural Biology, 2023, 80 pp. 102593 -
Publisher
CURRENT BIOLOGY LTD